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BDP9066

Name: BDP9066
Brand: TargetMol
SKU: T14521
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14521Cas No. 2226507-04-4

BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.

BDP9066

😃Good

Catalog No. T14521Cas No. 2226507-04-4

BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$198	8-10 weeks	8-10 weeks
25 mg	$455	8-10 weeks	8-10 weeks
50 mg	$787	8-10 weeks	8-10 weeks
100 mg	$1,360	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$135	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.
Targets&IC50	MRCKβ (SCC12 cells):64 nM, MRCKα/β:（ki）0.0136 nM/0.0233 nM, MRCKα/β:0.0136 nM/0.0233 nM ( Ki)
In vitro	Among over 750 human cancer cell lines tested, BDP9066 consistently exhibited anti-proliferative activity in hematologic cancer cells[1].
In vivo	As an effective and selective MRCK inhibitor, BDP9066, in a two-stage chemical carcinogenesis model of mouse squamous cell carcinoma, reduced MRCKα S1003 phosphorylation and the growth of skin tumors with local treatment.

Chemical Properties

Molecular Weight	348.44
Formula	C₂₀H₂₄N₆
Cas No.	2226507-04-4
Smiles	C1CC[C@@]2(CCCN(C2)c2cc[nH]c3ncc(-c4ccncn4)c23)NC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (22.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3497 mL	28.6993 mL	143.4967 mL
5 mM	0.5740 mL	2.8699 mL	5.7399 mL	28.6993 mL
10 mM	0.2870 mL	1.4350 mL	2.8699 mL	14.3497 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1748 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc