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EFdA-TP

Catalog No. T41110 CAS 950913-56-1

EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to as ICT and DCT, respectively. Additionally, EFdA-TP demonstrates its efficacy in inhibiting HIV-1 RT through multiple pathways.

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EFdA-TP, CAS 950913-56-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

EFdA-TP, in concentrations ranging from 0.05 to 10 μM for a duration of 15 minutes, acts as an immediate chain terminator (ICT) or delayed chain terminator (DCT) to inhibit reverse transcriptase (RT)-catalyzed DNA synthesis [1]. As a translocation-defective RT inhibitor, it significantly decelerates DNA synthesis, effectively acting as an immediate chain terminator, while also possessing the capability to function as a delayed chain terminator by permitting the addition of one more deoxynucleotide triphosphate (dNTP) prior to halting DNA synthesis [1].

Molecular Weight	533.195
Formula	C12H15FN5O12P3
CAS No.	950913-56-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Eleftherios Michailidis, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. J Biol Chem. 2014 Aug 29;289(35):24533-48. 2. Martin Markowitz, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor. Curr Opin HIV AIDS. 2018 Jul;13(4):294-299.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EFdA-TP 950913-56-1 EFdA TP EFdATP inhibitor inhibit

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