Shopping Cart

Your shopping cart is currently empty

SYN1143

Name: SYN1143
Brand: TargetMol
SKU: T8409
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T8409Cas No. 913376-84-8

Alias RON-IN-1, AMG-1

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

SYN1143

Copy Product Info

😃Good

Purity: 99.69%

Catalog No. T8409Alias RON-IN-1, AMG-1Cas No. 913376-84-8

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$52	-	In Stock
25 mg	$83	-	In Stock
50 mg	$125	-	In Stock
1 mL x 10 mM (in DMSO)	$41	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.69%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

SYN1143 AI Summary

SYN1143 exhibits potent bioactivities with high affinity for multiple targets related to cancer and malaria treatment. It is a strong inhibitor of c-Met, demonstrating a Ki value of 2.7 nM and an IC50 value of 50.0 nM in blocking HGF-mediated c-Met phosphorylation in human PC3 cells. Additionally, it inhibits VEGFR2 activity with a Ki of 1160.0 nM and an IC50 of 921.0 nM, suggesting its potential in antiangiogenic applications. The compound also shows specificity for c-Met over other kinases such as IGF1R and VEGFR2, with significantly higher Ki values for the latter kinases. Moreover, SYN1143 shows potent antimalarial activity by inhibiting Plasmodium falciparum proliferation, with varying potencies of 6.7 nM and 11875.4 nM in different assays. These properties indicate that SYN1143 holds promise for therapeutic applications in both anticancer and antimalarial treatments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.
Targets&IC50	c-Met:4 nM, RON:9 nM
Synonyms	RON-IN-1, AMG-1

Chemical Properties

Molecular Weight	556.58
Formula	C₃₁H₂₉FN₄O₅
Cas No.	913376-84-8
Smiles	COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (161.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7967 mL	8.9834 mL	17.9669 mL	89.8343 mL
5 mM	0.3593 mL	1.7967 mL	3.5934 mL	17.9669 mL
10 mM	0.1797 mL	0.8983 mL	1.7967 mL	8.9834 mL
20 mM	0.0898 mL	0.4492 mL	0.8983 mL	4.4917 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7967 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc