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SYN1143

Name: SYN1143
Brand: TargetMol
SKU: T8409
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8409Cas No. 913376-84-8

Alias RON-IN-1, AMG-1

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

SYN1143

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Purity: 99.69%

Catalog No. T8409Alias RON-IN-1, AMG-1Cas No. 913376-84-8

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$52	-	In Stock
25 mg	$83	-	In Stock
50 mg	$125	-	In Stock
1 mL x 10 mM (in DMSO)	$41	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.69%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.
Targets&IC50	RON:9 nM, c-Met:4 nM
Synonyms	RON-IN-1, AMG-1

Chemical Properties

Molecular Weight	556.58
Formula	C₃₁H₂₉FN₄O₅
Cas No.	913376-84-8
Smiles	COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (161.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7967 mL	8.9834 mL	17.9669 mL	89.8343 mL
5 mM	0.3593 mL	1.7967 mL	3.5934 mL	17.9669 mL
10 mM	0.1797 mL	0.8983 mL	1.7967 mL	8.9834 mL
20 mM	0.0898 mL	0.4492 mL	0.8983 mL	4.4917 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7967 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc