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Loratadine

Name: Loratadine
Brand: TargetMol
SKU: T1097
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1097Cas No. 79794-75-5

Alias SCH 29851, Loratidine

Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

Loratadine

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Purity: 99.98%

Catalog No. T1097Alias SCH 29851, LoratidineCas No. 79794-75-5

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$41	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Targets&IC50	B(0)AT2:4 μM
In vivo	Loratadine blocks Kv1.5 channels in a concentration-, voltage-, time-, and use-dependent manner when expressed in human Ltk-cells transfected with the hKv1.5 channel gene at concentrations exceeding therapeutic plasma levels. It also inhibits rhinovirus-induced upregulation of ICAM-1 in main bronchial or transformed respiratory epithelial cells. Identified as a selective inhibitor of B(0)AT 2 with an IC50 of 4 μM, loratadine exhibits low or no activity against several other members of the SLC6 family. Pre-incubation with loratadine concentration-dependently suppresses the release of histamine and LTC4 in human FcεRI+ cells upon challenge with Der p1 antigen or anti-FcεRI. In human umbilical vein endothelial cells, loratadine significantly inhibits histamine-induced secretion of IL-6 and IL-8, with its active metabolites showing even stronger effects. Additionally, loratadine in a dose-dependent manner inhibits the mRNA of ICAM-1 induced by rhinovirus infection and completely suppresses the activation of the rhinovirus-induced ICAM-1 promoter.
Synonyms	SCH 29851, Loratidine

Chemical Properties

Molecular Weight	382.88
Formula	C₂₂H₂₃ClN₂O₂
Cas No.	79794-75-5
Smiles	CCOC(=O)N1CC\C(CC1)=C1/C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2
Relative Density.	1.261 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 77 mg/mL (201.11 mM), Sonication is recommended.

DMSO: 25 mg/mL (65.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.6118 mL	13.0589 mL	26.1178 mL	130.5892 mL
5 mM	0.5224 mL	2.6118 mL	5.2236 mL	26.1178 mL
10 mM	0.2612 mL	1.3059 mL	2.6118 mL	13.0589 mL
20 mM	0.1306 mL	0.6529 mL	1.3059 mL	6.5295 mL
50 mM	0.0522 mL	0.2612 mL	0.5224 mL	2.6118 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0261 mL	0.1306 mL	0.2612 mL	1.3059 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc