Shopping Cart

Remove All
Your shopping cart is currently empty

I-OMe-Tyrphostin AG 538

Name: I-OMe-Tyrphostin AG 538
Brand: TargetMol
SKU: T11593
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11593Cas No. 1094048-77-7

Alias I-OMe-AG 538

I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells.

I-OMe-Tyrphostin AG 538

🥰Excellent

Purity: 98.23%

Catalog No. T11593Alias I-OMe-AG 538Cas No. 1094048-77-7

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$455	In Stock
50 mg	$672	In Stock
100 mg	$956	In Stock
500 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:98.23%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells.
Targets&IC50	PI5P4Kα:1 µM
In vitro	I-OMe Tyrhost AG 538 (0-3 µM; 1 hour) can prevent the phosphorylation of Akt, IGF-1R, and Erk.[1] I-OMe Tyrphostin AG 538 (0.1-1000 µM; 24 hours) has cytotoxicity on PANC-1 cells in nutrient deficient culture medium.[1]
Synonyms	I-OMe-AG 538

Chemical Properties

Molecular Weight	437.19
Formula	C₁₇H₁₂INO₅
Cas No.	1094048-77-7
Smiles	COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2873 mL	11.4367 mL	22.8734 mL	114.3668 mL
5 mM	0.4575 mL	2.2873 mL	4.5747 mL	22.8734 mL
10 mM	0.2287 mL	1.1437 mL	2.2873 mL	11.4367 mL
20 mM	0.1144 mL	0.5718 mL	1.1437 mL	5.7183 mL
50 mM	0.0457 mL	0.2287 mL	0.4575 mL	2.2873 mL
100 mM	0.0229 mL	0.1144 mL	0.2287 mL	1.1437 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc