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Vipivotide tetraxetan Linker

Name: Vipivotide tetraxetan Linker
Brand: TargetMol
SKU: T17233
Rating: 4.5 (1 reviews)

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Catalog No. T17233Cas No. 1703768-74-4

Alias PSMA-617 Linker

Vipivotide tetraxetan Linker (PSMA-617 Linker) is a noncleavable peptide linker utilized in the synthesis of Vipivotide tetraxetan (PSMA-617), a ligand instrumental in producing 177Lu-PSMA-617. This radioactive molecule is applied in the treatment of prostate cancer[1].

Vipivotide tetraxetan Linker

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Catalog No. T17233Alias PSMA-617 LinkerCas No. 1703768-74-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$83	7-10 days	7-10 days
10 mg	$114	7-10 days	7-10 days
25 mg	$214	7-10 days	7-10 days
50 mg	$357	7-10 days	7-10 days
100 mg	$643	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Vipivotide tetraxetan Linker (PSMA-617 Linker) is a noncleavable peptide linker utilized in the synthesis of Vipivotide tetraxetan (PSMA-617), a ligand instrumental in producing 177Lu-PSMA-617. This radioactive molecule is applied in the treatment of prostate cancer[1].
Synonyms	PSMA-617 Linker

Chemical Properties

Molecular Weight	655.74
Formula	C₃₃H₄₅N₅O₉
Cas No.	1703768-74-4
Smiles	NCC1CCC(CC1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCCCCC(NC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O
Relative Density.	1.303 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 270 mg/mL (411.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5250 mL	7.6250 mL	15.2499 mL	76.2497 mL
5 mM	0.3050 mL	1.5250 mL	3.0500 mL	15.2499 mL
10 mM	0.1525 mL	0.7625 mL	1.5250 mL	7.6250 mL
20 mM	0.0762 mL	0.3812 mL	0.7625 mL	3.8125 mL
50 mM	0.0305 mL	0.1525 mL	0.3050 mL	1.5250 mL
100 mM	0.0152 mL	0.0762 mL	0.1525 mL	0.7625 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc