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Senazodan hydrochloride

Name: Senazodan hydrochloride
Brand: TargetMol
SKU: T28752
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28752Cas No. 98326-33-1

Alias Senazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HCl

Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.

Senazodan hydrochloride

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Purity: 99.93%

Catalog No. T28752Alias Senazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HClCas No. 98326-33-1

Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,180	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Viscous

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.
In vitro	Senazodan hydrochloride appears to modulate actin-myosin cross-bridge dynamics and promote myosin ATPase activity [1]. Senazodan hydrochloride increases tonogenesis in a concentration-dependent manner while enhancing the binding capacity of calcium ions (Ca²⁺) to myofilaments as well as purified cardiac troponin C. The binding capacity of calcium ions to myofilaments is also enhanced by Senazodan hydrochloride. In addition, cenazolone hydrochloride improves contractile properties of guinea pig papillary muscle by inhibiting phosphodiesterase III (PDE III) [2]. Senazodan hydrochloride attenuated the contractile response induced by norepinephrine (NE) on the superior mesenteric artery (SMA) after hemorrhagic shock over the concentration range of 0.1 nM to 0.1 mM, which was significantly reduced compared to normal controls. 0.01 mM Senazodan hydrochloride pretreatment was able to inhibit the contraction of angiotensin II (Ang II) in guinea pigs. The effect of angiotensin II (Ang II) was significantly shifted to the right of the calcium concentration-response curve, which was more prominent in the Ang II group compared to the Ang II group alone. [3]
In vivo	0.1 to 2.0 mg/kg Senazodan hydrochloride infused through a femoral vein catheter reduces the antihypertensive effect of norepinephrine (NE). [3] Intravenous infusion of 0.1 mg/kg Senazodan hydrochloride significantly elevated left ventricular systolic pressure (LVSP), myocardial contractility (IP), myocardial contractility (MC), and left ventricular output (Lo) without significant changes in heart rate. Meanwhile, left ventricular end-diastolic pressure (LVEDP) was significantly decreased. [4]
Synonyms	Senazodan HCl, MCI-154 HCl, MCI154 HCl, MCI 154 HCl

Chemical Properties

Molecular Weight	302.76
Formula	C₁₅H₁₅ClN₄O
Cas No.	98326-33-1
Smiles	Cl.O=C1NN=C(C=2C=CC(=CC2)NC=3C=CN=CC3)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (165.15 mM), Sonication is recommended.

H2O: 20 mg/mL (66.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3029 mL	16.5147 mL	33.0295 mL	165.1473 mL
5 mM	0.6606 mL	3.3029 mL	6.6059 mL	33.0295 mL
10 mM	0.3303 mL	1.6515 mL	3.3029 mL	16.5147 mL
20 mM	0.1651 mL	0.8257 mL	1.6515 mL	8.2574 mL
50 mM	0.0661 mL	0.3303 mL	0.6606 mL	3.3029 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0330 mL	0.1651 mL	0.3303 mL	1.6515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc