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Bozitinib

Name: Bozitinib
Brand: TargetMol
SKU: T10585
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10585Cas No. 1440964-89-5

Alias PLB-1001, CBT-101

Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.

Bozitinib

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Purity: 99.16%

Catalog No. T10585Alias PLB-1001, CBT-101Cas No. 1440964-89-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$662	In Stock	In Stock
50 mg	$953	In Stock	In Stock
100 mg	$1,330	In Stock	In Stock
200 mg	$1,790	-	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.16%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.
In vitro	Bozitinib (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3. Bozitinib has a robust inhibitory effect on MET and its downstream signaling pathways.
Synonyms	PLB-1001, CBT-101

Chemical Properties

Molecular Weight	424.38
Formula	C₂₀H₁₅F₃N₈
Cas No.	1440964-89-5
Smiles	Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1
Relative Density.	1.68 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (110.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3564 mL	11.7819 mL	23.5638 mL	117.8189 mL
5 mM	0.4713 mL	2.3564 mL	4.7128 mL	23.5638 mL
10 mM	0.2356 mL	1.1782 mL	2.3564 mL	11.7819 mL
20 mM	0.1178 mL	0.5891 mL	1.1782 mL	5.8909 mL
50 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3564 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	1.1782 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc