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5-O-Caffeoylshikimic acid

Name: 5-O-Caffeoylshikimic acid
Brand: TargetMol
SKU: TN1295
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1295Cas No. 73263-62-4

5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.

5-O-Caffeoylshikimic acid

🥰Excellent

Purity: 99.82%

Catalog No. TN1295Cas No. 73263-62-4

5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$259	In Stock
10 mg	$386	In Stock
25 mg	$635	In Stock
50 mg	$893	In Stock
100 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$268	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
Targets&IC50	XOD:13.96 μM
In vitro	Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1]

Chemical Properties

Molecular Weight	336.29
Formula	C₁₆H₁₆O₈
Cas No.	73263-62-4
Smiles	O[C@@H]1C=C(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)C(O)=O
Relative Density.	1.60 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (148.68 mM), Sonication is recommended.

H2O: 20 mg/mL (59.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9736 mL	14.8681 mL	29.7362 mL	148.6812 mL
5 mM	0.5947 mL	2.9736 mL	5.9472 mL	29.7362 mL
10 mM	0.2974 mL	1.4868 mL	2.9736 mL	14.8681 mL
20 mM	0.1487 mL	0.7434 mL	1.4868 mL	7.4341 mL
50 mM	0.0595 mL	0.2974 mL	0.5947 mL	2.9736 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4868 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc