Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AR-C141990 hydrochloride is a potent inhibitor of lactate transporters known as monocarboxylate transporters (MCTs). It has pK i values of 7.6 and 6.6 for MCT-1 and MCT-2, respectively. Additionally, this compound exhibits immunosuppressive properties and effectively inhibits the graft versus host response.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 785.00 |
Description | AR-C141990 hydrochloride is a potent inhibitor of lactate transporters known as monocarboxylate transporters (MCTs). It has pK i values of 7.6 and 6.6 for MCT-1 and MCT-2, respectively. Additionally, this compound exhibits immunosuppressive properties and effectively inhibits the graft versus host response. |
In vitro | AR-C141990 hydrochloride exhibits negligible activity against MCT-3 (pIC 50 <5) and MCT-4 (pIC 50 <5)[1]. However, it effectively inhibits the uptake of [3H]HOCPCA in oocytes expressing MCT1 or 2, demonstrating concentration-dependent inhibition with IC50 values of 0.21 μM for MCT1 and 2.32 μM for MCT2, respectively[2]. |
In vivo | Administering AR-C141990 hydrochloride (10 mg/kg; SC) to male NMRI mice (18-22 g) resulted in a rapid decrease in its plasma concentrations, exhibiting a half-life of approximately 20 minutes[2]. The plasma levels of AR-C141990 hydrochloride (0.3-90 mg/kg) were found to reduce the B/P of HOCPCA in a concentration-dependent manner, with an EC50 of 860 ng/ml[2]. Furthermore, a dose of AR-C141990 (100 mg/kg; s.c.) was observed to moderately extend the survival of grafts to 40 days in PVG rats that underwent DA cardiac transplants[1]. |
Synonyms | AR-C141990 hydrochloride |
Molecular Weight | 529.05 |
Formula | C26H29ClN4O4S |
CAS No. | 2250019-94-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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