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Leucylarginylproline

Name: Leucylarginylproline
Brand: TargetMol
SKU: T7510
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7510Cas No. 133943-59-6

Leucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).

Leucylarginylproline

🥰Excellent

Purity: 99.58%

Catalog No. T7510Cas No. 133943-59-6

Leucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$342	In Stock
10 mg	$513	In Stock
25 mg	$762	In Stock
50 mg	$1,130	In Stock
100 mg	$1,530	In Stock
1 mL x 10 mM (in DMSO)	$317	In Stock

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Purity:99.58%

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COA LCMS

Product Introduction

Bioactivity

Description	Leucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).
Targets&IC50	ACE:0.27μM
In vivo	Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration[1]

Chemical Properties

Molecular Weight	384.47
Formula	C₁₇H₃₂N₆O₄
Cas No.	133943-59-6
Smiles	C([C@@H](NC([C@H](CC(C)C)N)=O)CCCNC(=N)N)(=O)N1[C@H](C(O)=O)CCC1
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (31.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6010 mL	13.0049 mL	26.0098 mL	130.0492 mL
5 mM	0.5202 mL	2.6010 mL	5.2020 mL	26.0098 mL
10 mM	0.2601 mL	1.3005 mL	2.6010 mL	13.0049 mL
20 mM	0.1300 mL	0.6502 mL	1.3005 mL	6.5025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc