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Gemcabene

Name: Gemcabene
Brand: TargetMol
SKU: T11386L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11386LCas No. 183293-82-5

Alias PD-72953

Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-inflammatory acute-phase protein, C-reactive protei

Gemcabene

🥰Excellent

Catalog No. T11386LAlias PD-72953Cas No. 183293-82-5

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$60	In Stock
10 mg	$98	In Stock
25 mg	$226	In Stock
50 mg	$383	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

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COA HNMR

Product Introduction

Bioactivity

Description	Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-inflammatory acute-phase protein, C-reactive protei
In vitro	Gemcabene significantly downregulates hepatic mRNA markers of inflammation including TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB, lipogenesis, fibrosis including TIMP-1 and MMP-2, and lipid modulation including ApoC-III, ACC1, ADH-4 and Sulf-2[2].
Synonyms	PD-72953

Chemical Properties

Molecular Weight	302.41
Formula	C₁₆H₃₀O₅
Cas No.	183293-82-5
Smiles	CC(C)(CCCCOCCCCC(C)(C)C(O)=O)C(O)=O
Relative Density.	1.048 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (314.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3068 mL	16.5338 mL	33.0677 mL	165.3384 mL
5 mM	0.6614 mL	3.3068 mL	6.6135 mL	33.0677 mL
10 mM	0.3307 mL	1.6534 mL	3.3068 mL	16.5338 mL
20 mM	0.1653 mL	0.8267 mL	1.6534 mL	8.2669 mL
50 mM	0.0661 mL	0.3307 mL	0.6614 mL	3.3068 mL
100 mM	0.0331 mL	0.1653 mL	0.3307 mL	1.6534 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc