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Cirazoline hydrochloride
🥰Excellent
Catalog No. T14972Cas No. 40600-13-3
Alias LD3098 hydrochloride
Cirazoline hydrochloride is a synthetic compound that acts as a competitive full agonist of the α1A-adrenergic receptor (α1A-AR) with a binding affinity of Ki = 120 nM, and Cirazoline hydrochloride also functions as a partial agonist at α1B-AR (Ki = 960 nM) and α1D-AR (Ki = 660 nM), thereby serving as a versatile adrenergic receptor probe with relevance for studying vascular tone regulation, adrenergic pharmacology, and potential therapeutic cardiovascular applications.
Cirazoline hydrochloride
🥰Excellent
Purity: 99.863%
Catalog No. T14972Alias LD3098 hydrochlorideCas No. 40600-13-3
Cirazoline hydrochloride is a synthetic compound that acts as a competitive full agonist of the α1A-adrenergic receptor (α1A-AR) with a binding affinity of Ki = 120 nM, and Cirazoline hydrochloride also functions as a partial agonist at α1B-AR (Ki = 960 nM) and α1D-AR (Ki = 660 nM), thereby serving as a versatile adrenergic receptor probe with relevance for studying vascular tone regulation, adrenergic pharmacology, and potential therapeutic cardiovascular applications.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $213 | In Stock | |
| 25 mg | $359 | In Stock | |
| 50 mg | $533 | In Stock | |
| 100 mg | $759 | In Stock | |
| 200 mg | $987 | In Stock |
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Purity:99.863%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cirazoline hydrochloride is a synthetic compound that acts as a competitive full agonist of the α1A-adrenergic receptor (α1A-AR) with a binding affinity of Ki = 120 nM, and Cirazoline hydrochloride also functions as a partial agonist at α1B-AR (Ki = 960 nM) and α1D-AR (Ki = 660 nM), thereby serving as a versatile adrenergic receptor probe with relevance for studying vascular tone regulation, adrenergic pharmacology, and potential therapeutic cardiovascular applications. |
| Targets&IC50 | AR-α1A:120 nM (Ki), AR-α1B:960 nM (Ki), AR-α1D:660 nM (Ki) |
| In vitro | Methods: Glioblastoma-initiating cells were treated with cirazoline hydrochloride (5-10 μM, 24 hours), and cell viability was measured using the WST-1 reduction assay. Results: Cirazoline hydrochloride did not alter the viability of GICs and only slightly antagonized prazosin-induced GIC death. [2] |
| In vivo | Methods: B6/CBA mice were treated with Cirazoline hydrochloride (drinking water, 40 μM, for 9 months) to investigate the influence of α1A-AR signaling in antidepressant effects. Results: Wild-type mice with long-term intake of Cirazoline hydrochloride showed a significant reduction in immobility time during the TST (tail suspension test). [1]. |
| Synonyms | LD3098 hydrochloride |
| Molecular Weight | 252.74 |
| Formula | C13H17ClN2O |
| Cas No. | 40600-13-3 |
| Smiles | Cl.N1=C(NCC1)COC=2C=CC=CC2C3CC3 |
| Relative Density. | 1.25g/cm3 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 24 mg/mL (94.96 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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