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Cirazoline hydrochloride

Name: Cirazoline hydrochloride
Brand: TargetMol
SKU: T14972
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14972Cas No. 40600-13-3

Alias LD3098 hydrochloride

Cirazoline hydrochloride is a synthetic compound that acts as a competitive full agonist of the α1A-adrenergic receptor (α1A-AR) with a binding affinity of Ki = 120 nM, and Cirazoline hydrochloride also functions as a partial agonist at α1B-AR (Ki = 960 nM) and α1D-AR (Ki = 660 nM), thereby serving as a versatile adrenergic receptor probe with relevance for studying vascular tone regulation, adrenergic pharmacology, and potential therapeutic cardiovascular applications.

Cirazoline hydrochloride

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Purity: 99.86%

Catalog No. T14972Alias LD3098 hydrochlorideCas No. 40600-13-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$139	-	In Stock
10 mg	$213	-	In Stock
25 mg	$359	-	In Stock
50 mg	$533	-	In Stock
100 mg	$759	-	In Stock
200 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cirazoline hydrochloride is a synthetic compound that acts as a competitive full agonist of the α1A-adrenergic receptor (α1A-AR) with a binding affinity of Ki = 120 nM, and Cirazoline hydrochloride also functions as a partial agonist at α1B-AR (Ki = 960 nM) and α1D-AR (Ki = 660 nM), thereby serving as a versatile adrenergic receptor probe with relevance for studying vascular tone regulation, adrenergic pharmacology, and potential therapeutic cardiovascular applications.
Targets&IC50	AR-α1D:660 nM (Ki), AR-α1A:120 nM (Ki), AR-α1B:960 nM (Ki)
In vitro	Methods: Glioblastoma-initiating cells were treated with cirazoline hydrochloride (5-10 μM, 24 hours), and cell viability was measured using the WST-1 reduction assay. Results: Cirazoline hydrochloride did not alter the viability of GICs and only slightly antagonized prazosin-induced GIC death. [2]
In vivo	Methods: B6/CBA mice were treated with Cirazoline hydrochloride (drinking water, 40 μM, for 9 months) to investigate the influence of α1A-AR signaling in antidepressant effects. Results: Wild-type mice with long-term intake of Cirazoline hydrochloride showed a significant reduction in immobility time during the TST (tail suspension test). [1].
Synonyms	LD3098 hydrochloride

Chemical Properties

Molecular Weight	252.74
Formula	C₁₃H₁₇ClN₂O
Cas No.	40600-13-3
Smiles	Cl.N1=C(NCC1)COC=2C=CC=CC2C3CC3
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 24 mg/mL (94.96 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.9566 mL	19.7832 mL	39.5664 mL	197.8318 mL
5 mM	0.7913 mL	3.9566 mL	7.9133 mL	39.5664 mL
10 mM	0.3957 mL	1.9783 mL	3.9566 mL	19.7832 mL
20 mM	0.1978 mL	0.9892 mL	1.9783 mL	9.8916 mL
50 mM	0.0791 mL	0.3957 mL	0.7913 mL	3.9566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc