store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 722.00 |
Description | Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC). |
In vitro |
Glembatumumab vedotin binds to GPNMB on tumor cells, and the complex is internalized. Within the lysosomal compartment, the protein linker containing monomethyl auristatin E (MMAE) is enzymatically cleaved, releasing MMAE. MMAE inhibits microtubules, leading to cell cycle arrest and subsequent tumor cell death[1]. Glembatumumab vedotin exhibits cytotoxic activity against osteosarcoma cells at concentrations ranging from 1 to 125 μg/mL over a 96-hour period[2]. |
In vivo | In human SK-MEL-2 and SK-MEL-5 melanoma xenograft models, Glembatumumab vedotin (CR011-vcMMAE) demonstrates both short-term antitumor effects (inhibiting tumor growth) and long-term effects (complete regression) when administered via intravenous injection at doses ranging from 1.25 to 80 mg/kg, every 4 days, for a duration of 16 days[3]. |
Synonyms | CR011-vcMMAE, CR 011 ADC, CDX-011 |
Molecular Weight | N/A |
CAS No. | 1182215-65-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Glembatumumab vedotin 1182215-65-1 Cytoskeletal Signaling Microtubule Associated CR011-vcMMAE CR 011 ADC CDX-011 inhibitor inhibit