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Tafenoquine
🥰Excellent
Catalog No. T13083Cas No. 106635-80-7
Alias WR238605, WR 238605
Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research.
Tafenoquine
🥰Excellent
Purity: 99.56%
Catalog No. T13083Alias WR238605, WR 238605Cas No. 106635-80-7
Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $91 | In Stock | |
| 25 mg | $193 | In Stock | |
| 50 mg | $312 | In Stock | |
| 100 mg | $496 | In Stock |
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Purity:99.56%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research. |
| In vitro | Methods: Tafenoquine (WR 238605) was treated with macrophage cell line RAW 264.7, and the in vitro toxicity was evaluated using the MTT assay after 24 hours. Results: The IC50 value of Tafenoquine against macrophage cell line RAW 264.7 was 5.9μg/mL.[1] |
| In vivo | Methods: Tafenoquine (WR 238605) (3/6mg/kg, oral) was administered to normal C57BL/6 mice (WT) and humanized/CYP 2D6 knock-in mice, and the antimalarial activity of TQ against P. berghei expressing enzymes was evaluated by monitoring luminescence using an in vivo imaging system. Results: Tafenoquine at a dose of 3mg/kg showed no antimalarial activity in CYP 2D knock-out mice; when tested at 6mg/kg, the antimalarial activity of TQ in humanized/CYP 2D6 knock-in mice was partially restored.[1] |
| Synonyms | WR238605, WR 238605 |
| Molecular Weight | 463.49 |
| Formula | C24H28F3N3O3 |
| Cas No. | 106635-80-7 |
| Smiles | FC(F)(F)C=1C=CC=C(OC2=C(OC)C=C(NC(C)CCCN)C3=NC(OC)=CC(=C32)C)C1 |
| Relative Density. | 1.237 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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