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Amlodipine

Name: Amlodipine
Brand: TargetMol
SKU: T1385
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1385Cas No. 88150-42-9

Alias UK-48340

Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.

Amlodipine

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Purity: 99.60%

Catalog No. T1385Alias UK-48340Cas No. 88150-42-9

Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$45	-	In Stock
1 g	$72	-	In Stock
2 g	$98	-	In Stock
5 g	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.60%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
In vitro	In large coronary arteries and aorta, Amlodipine increased nitrite production. Intracellularly, Amlodipine caused neuronal Ca2+ elevation by attenuating KCl depolarization.
In vivo	In large coronary arteries and aorta, Amlodipine increased nitrite production. Intracellularly, Amlodipine caused neuronal Ca2+ elevation by attenuating KCl depolarization.
Synonyms	UK-48340

Chemical Properties

Molecular Weight	408.88
Formula	C₂₀H₂₅ClN₂O₅
Cas No.	88150-42-9
Smiles	OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
Relative Density.	1.227 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (220.11 mM), Sonication is recommended.

Ethanol: 76 mg/mL (185.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4457 mL	12.2285 mL	24.4571 mL	122.2853 mL
5 mM	0.4891 mL	2.4457 mL	4.8914 mL	24.4571 mL
10 mM	0.2446 mL	1.2229 mL	2.4457 mL	12.2285 mL
20 mM	0.1223 mL	0.6114 mL	1.2229 mL	6.1143 mL
50 mM	0.0489 mL	0.2446 mL	0.4891 mL	2.4457 mL
100 mM	0.0245 mL	0.1223 mL	0.2446 mL	1.2229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc