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Pentoxifylline
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Catalog No. T0070Cas No. 6493-05-6
Alias PTX, Oxpentifylline, BL-191
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet aggregation and improves blood flow by increasing erythrocyte and leukocyte flexibility.
Pentoxifylline
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Purity: 99.93%
Catalog No. T0070Alias PTX, Oxpentifylline, BL-191Cas No. 6493-05-6
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet aggregation and improves blood flow by increasing erythrocyte and leukocyte flexibility.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $40 | - | In Stock | |
| 1 g | $48 | - | In Stock | |
| 5 g | $113 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
Pentoxifylline AI Summary
Pentoxifylline exhibits diverse bioactivities across multiple biological pathways and processes. It has a volume of distribution in humans of 4.2 L.kg-1 and a high unbound fraction in plasma (Fu = 1.0) but lower in tissues (Fu = 0.095), suggesting significant systemic distribution after intravenous dosing. The compound is slightly lipophilic with a logD value of 0.29 and demonstrates a partition coefficient (logP) of around 0.3, impacting its absorption, distribution, metabolism, and excretion (ADME) properties.
In bioactivity assays, Pentoxifylline inhibits tumor necrosis factor-alpha (TNF-alpha) production with variable IC50 values (e.g., 33,000 nM in certain assays and up to 85,000 nM in peripheral blood mononuclear cells). It also shows anti-inflammatory actions, notably inhibiting TNFalpha and nitric oxide production in mouse macrophage cell lines. Additionally, it has been tested against several pathogens, with both antibacterial and antifungal activities displaying various degrees of inhibition.
Pharmacokinetic data show rapid clearance (39 mL.min-1.kg-1), a short half-life (1.2 hours), and mean residence time (0.77 hours). The compound has demonstrated moderate oral bioavailability (49%) in humans.
Pentoxifylline also affects liver and kidney functions, as indicated by alterations in enzyme levels (ALT, ALP, AST, BUN) in specific assays, suggesting potential hepatotoxicity and nephrotoxicity. Despite its inhibitory activities, the compound has weak inhibition against enzymes like PDE4A and HDAC6, with IC50 values generally greater than 90,000 nM.
Lastly, the compound shows some antiviral activity against SARS-CoV-2, although with limited efficacy (IC50 values around 20,000 nM) and low binding affinity towards several targets, reflecting its modest impact on viral protease and cytotoxicity assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet aggregation and improves blood flow by increasing erythrocyte and leukocyte flexibility. |
| Synonyms | PTX, Oxpentifylline, BL-191 |
| Molecular Weight | 278.31 |
| Formula | C13H18N4O3 |
| Cas No. | 6493-05-6 |
| Smiles | O=C1C2=C(N(C)C(=O)N1CCCCC(C)=O)N=CN2C |
| Relative Density. | 1.1713 g/cm3 (Estimated) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50.8 mg/mL (182.53 mM), Sonication is recommended.  DMSO: 49 mg/mL (176.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
venousvasculopathiesvasculitidesulcerspurpuricpigmentedPhosphodiesterase (PDE)phosphodiesteraseperipheral vascularPentoxifyllinePDEmethyl-xanthineleprosylegintermittentInhibitorinhibitimmunomodulatorHuman immunodeficiency virusHIVProteaseHIV ProteaseHIVhemorrheologichemorheologicaldiseasesdermatosesdermatologicalclaudicationBL191BL 191Autophagyanti-hypercholesterolemicAdenosineReceptorAdenosine ReceptorA2
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