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Levosulpiride

Name: Levosulpiride
Brand: TargetMol
SKU: T1211
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1211Cas No. 23672-07-3

Alias S-(-)-Sulpiride, RV-12309

Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.

Levosulpiride

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Purity: 99.88%

Catalog No. T1211Alias S-(-)-Sulpiride, RV-12309Cas No. 23672-07-3

Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$37	In Stock	In Stock
100 mg	$50	In Stock	In Stock
500 mg	$113	In Stock	In Stock
1 g	$163	In Stock	-
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Levosulpiride AI Summary

Levosulpiride exhibits a broad spectrum of bioactivities, prominently involving dopamine receptor modulation and antipsychotic effects. It shows high affinity for dopamine receptors, particularly D2 with varying Ki values (e.g., 6.9 nM, 20.6 nM, 39.0 nM), and also demonstrates interaction with receptors D1, D2L, D2 short, D3, and D4. It effectively inhibits D2 receptor binding as evidenced by IC50 values like 210.0 nM. In vivo, Levosulpiride antagonizes apomorphine-induced hyperactivity and stereotypies in rats, displaying ED50 values around 28.2 μmol/kg to 290.0 μmol/kg depending on the specific behavior assessed. Furthermore, it induces catalepsy with an ED50 of approximately 280.0 μmol/kg after intraperitoneal administration. Beyond dopaminergic activity, Levosulpiride shows low binding affinity for serotonin and alpha-1 adrenergic receptors (Ki values > 1000 nM). Notably, it exhibits moderate antiviral activity against SARS-CoV-2, inhibitory effects on specific enzymes like human HDAC6 and myeloperoxidase (IC50: 7680.0 nM for MPO), and antifungal and antibacterial properties. Understanding its diverse bioactivity and mechanistic pathways can inform further research on its potential therapeutic applications, especially in neurological disorders and infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.
Synonyms	S-(-)-Sulpiride, RV-12309

Chemical Properties

Molecular Weight	341.43
Formula	C₁₅H₂₃N₃O₄S
Cas No.	23672-07-3
Smiles	C(NC[C@H]1N(CC)CCC1)(=O)C2=C(OC)C=CC(S(N)(=O)=O)=C2
Relative Density.	1.236 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (131.8 mM), Sonication is recommended.

Ethanol: 3.4 mg/mL (9.96 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9289 mL	14.6443 mL	29.2886 mL	146.4429 mL
5 mM	0.5858 mL	2.9289 mL	5.8577 mL	29.2886 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2929 mL	1.4644 mL	2.9289 mL	14.6443 mL
20 mM	0.1464 mL	0.7322 mL	1.4644 mL	7.3221 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	2.9289 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4644 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc