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Anti-PD-1 Antibody (5R506)
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Catalog No. TMAH-00863
Alias PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H
Anti-PD-1 Antibody (5R506) is a Mouse antibody targeting PD-1. Anti-PD-1 Antibody (5R506) can be used in ELISA,WB.
Anti-PD-1 Antibody (5R506)
Anti-PD-1 Antibody (5R506)
😃Good
Catalog No. TMAH-00863Alias PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H
Anti-PD-1 Antibody (5R506) is a Mouse antibody targeting PD-1. Anti-PD-1 Antibody (5R506) can be used in ELISA,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PD-1 Antibody (5R506) is a Mouse antibody targeting PD-1. Anti-PD-1 Antibody (5R506) can be used in ELISA,WB. |
| Synonyms | PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H |
| Ig Type | IgG1 |
| Clone | 5R506 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: 5μg 293 whole cell lysate transfected with PD-1, 25ng recombinant protein from E.coli, 25ng recombinant protein from Mammalian cell PD-1 antibody at 1:1000 -Secondary: Goat polyclonal to mouse IgG at 1/50000 dilution -Predicted band size: 72, 36 KDa -Observed band size: 72, 36 KDa -Exposure time：5min |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Programmed cell death Protein 1 Protein (21-170AA) |
| Antigen Species | Human |
| Gene Name | PDCD1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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