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SGC3027

Name: SGC3027
Brand: TargetMol
SKU: T12887
Rating: 4.5 (1 reviews)

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Catalog No. T12887

SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.

SGC3027

😃Good

Catalog No. T12887

SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description	SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.
In vitro	SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases.SGC3027 inhibits the methylation of HSP70(IC50=1.3 μM, in cellular assays using C2C12 cells)[2].

Chemical Properties

Molecular Weight	787.37
Formula	C₄₁H₄₇ClN₆O₆S
Smiles	ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (317.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2701 mL	6.3503 mL	12.7005 mL	63.5025 mL
5 mM	0.2540 mL	1.2701 mL	2.5401 mL	12.7005 mL
10 mM	0.1270 mL	0.6350 mL	1.2701 mL	6.3503 mL
20 mM	0.0635 mL	0.3175 mL	0.6350 mL	3.1751 mL
50 mM	0.0254 mL	0.1270 mL	0.2540 mL	1.2701 mL
100 mM	0.0127 mL	0.0635 mL	0.1270 mL	0.6350 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc