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Lumasiran

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Catalog No. T39273Cas No. 1834610-13-7
Alias ALN-G01

Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

Lumasiran

Lumasiran

😃Good
Catalog No. T39273Alias ALN-G01Cas No. 1834610-13-7
Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$1592-4 weeks2-4 weeks
5 mg$4112-4 weeks2-4 weeks
10 mg$6422-4 weeks2-4 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
In vitro
Lumasiran effectively decreased the excretion of urinary oxalate, which is responsible for the progression of kidney failure in patients with Primary Hyperoxaluria Type 1 (PH1)[1].
In vivo
Lumasiran sodium is a subcutaneously administered, liver-directed RNA interference (RNAi) therapeutic agent[2].
SynonymsALN-G01
Chemical Properties
Cas No.1834610-13-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Lumasiran
Related Tags: buy Lumasiran | purchase Lumasiran | Lumasiran cost | order Lumasiran | Lumasiran chemical structure | Lumasiran in vivo | Lumasiran in vitro
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