Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

NG,NG-dimethyl-L-Arginine dihydrochloride

🥰Excellent
Catalog No. T21546Cas No. 220805-22-1

NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].

NG,NG-dimethyl-L-Arginine dihydrochloride

NG,NG-dimethyl-L-Arginine dihydrochloride

🥰Excellent
Purity: 99.18%
Catalog No. T21546Cas No. 220805-22-1
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$43-In Stock
5 mg$94-In Stock
10 mg$173-In Stock
25 mg$289-In Stock
50 mg$428-In Stock
1 mL x 10 mM (in DMSO)$149-In Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.18%
Contact us for more batch information

Resource Download

COA HNMR

Product Introduction

Bioactivity
Description
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
In vitro
NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].
In vivo
Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
Chemical Properties
Molecular Weight275.18
FormulaC8H20Cl2N4O2
Cas No.220805-22-1
SmilesN[C@@H](CCCNC(N(C)C)=N)C(O)=O.[H]Cl.[H]Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 11 mg/mL (39.97 mM), Sonication is recommended.
DMSO: 7 mg/mL (25.44 mM), Sonication is recommended.
H2O: 14 mg/mL (50.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol/H2O
1mg5mg10mg50mg
1 mM3.6340 mL18.1699 mL36.3399 mL181.6993 mL
5 mM0.7268 mL3.6340 mL7.2680 mL36.3399 mL
10 mM0.3634 mL1.8170 mL3.6340 mL18.1699 mL
20 mM0.1817 mL0.9085 mL1.8170 mL9.0850 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NOSynthaseNO Synthasenitric oxideNG,NG-dimethyl-L-Arginine DihydrochlorideNG,NGdimethylLArginine dihydrochlorideNG,NG-dimethyl-L-ArginineNG,NG dimethyl L Arginine dihydrochloride
Related Tags: buy NG,NG-dimethyl-L-Arginine dihydrochloride | purchase NG,NG-dimethyl-L-Arginine dihydrochloride | NG,NG-dimethyl-L-Arginine dihydrochloride cost | order NG,NG-dimethyl-L-Arginine dihydrochloride | NG,NG-dimethyl-L-Arginine dihydrochloride chemical structure | NG,NG-dimethyl-L-Arginine dihydrochloride in vivo | NG,NG-dimethyl-L-Arginine dihydrochloride in vitro | NG,NG-dimethyl-L-Arginine dihydrochloride formula | NG,NG-dimethyl-L-Arginine dihydrochloride molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.