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TGFBR1 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPJ-01178
Synonyms: ALK-5, ALK-5ALK5, TGFβRI, tβR-I, LDS1A, TGFbetaRI, TGFB1R1, activin A receptor type II-like kinase, 53kD, TGF-β receptor type I, LDS2A, TGF-bRI, ACVRLK4, TGFR-1, SKR4, TGFBR1, TGF-beta receptor type I, AAT5, tbetaR-I

TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TGFBR1 Protein, Mouse, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 140.00
50 μg 5 days $ 423.00
500 μg 5 days $ 2,120.00
1 mg 5 days $ 3,170.00
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Biological Description
Technical Params
Product Properties
Description TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.
Species Mouse
Expression System Human Cells
Tag C-Fc
Accession Number Q64729
Synonyms ALK-5, ALK-5ALK5, TGFβRI, tβR-I, LDS1A, TGFbetaRI, TGFB1R1, activin A receptor type II-like kinase, 53kD, TGF-β receptor type I, LDS2A, TGF-bRI, ACVRLK4, TGFR-1, SKR4, TGFBR1, TGF-beta receptor type I, AAT5, tbetaR-I
Amino Acid Leu30-Glu125
Construction Recombinant Mouse TGF-beta Receptor Type-1 is produced by our Mammalian expression system and the target gene encoding Leu30-Glu125 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 40-60 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.

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Keywords

TGFBR1 Protein, Mouse, Recombinant (hFc) ALK-5 ALK-5ALK5 TGFβRI ACVRLK 4 tβR-I SKR 4 LDS1A TGFbetaRI TGFB1R1 TGF-b receptor type I ALK5 activin A receptor type II-like kinase, 53kD TGF-β receptor type I ACVRLK-4 LDS2A SKR-4 TGF-bRI AAT 5 TGFBR-1 ACVRLK4 AAT-5 TGFR-1 SKR4 TGFBR1 TGF-beta receptor type I TGFR 1 TGFR1 ALK 5 TGFBR 1 AAT5 tbetaR-I recombinant recombinant-proteins proteins protein

 

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