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ORM-10921

Name: ORM-10921
Brand: TargetMol
SKU: T28267
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28267Cas No. 610782-82-6

Alias ORM10921, ORM 10921

ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.

ORM-10921

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Purity: 99.98%

Catalog No. T28267Alias ORM10921, ORM 10921Cas No. 610782-82-6

ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$397	In Stock	In Stock
5 mg	$970	In Stock	In Stock
10 mg	$1,290	In Stock	In Stock
25 mg	$1,950	In Stock	In Stock
50 mg	$2,620	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

ee:98.164%

Appearance:Solid

Color:White

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
Targets&IC50	α2C-adrenoceptor:1.4 nM (Ki)
In vivo	The role of the α2C-AR in modulating two key depression-related behaviors in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0.03, 0.3 mg/kg), the nonselective α2-AR antagonist idazoxan (3 mg/kg), or vehicle once daily for 14 days. Behavior in the novel object recognition test forced swim test (FST), and locomotor activity test was assessed. ORM-10921 at both doses but not idazoxan significantly reversed immobility in the FST as well as attenuated cognitive deficits in FSL animals.[3]
Synonyms	ORM10921, ORM 10921

Chemical Properties

Molecular Weight	285.38
Formula	C₁₈H₂₃NO₂
Cas No.	610782-82-6
Smiles	C(OC)[C@]1(C)[C@]2(C3=C(C=4C(O3)=CC=CC4)CCN2CCC1)[H]
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (157.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5041 mL	17.5205 mL	35.0410 mL	175.2050 mL
5 mM	0.7008 mL	3.5041 mL	7.0082 mL	35.0410 mL
10 mM	0.3504 mL	1.7520 mL	3.5041 mL	17.5205 mL
20 mM	0.1752 mL	0.8760 mL	1.7520 mL	8.7602 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	3.5041 mL
100 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc