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Anti-CTLA-4/CD152 Antibody
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Catalog No. T9901A-1254
Anti-CTLA-4/CD152 Antibody is a humanized monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4/CD152). This product specifically binds to the extracellular domain of CTLA-4, blocking its interaction with ligands CD80 (B7-1) and CD86 (B7-2). This blockade removes the negative regulatory signal of CTLA-4 on T-cell activation, thereby enhancing T-cell proliferation, cytokine production, and anti-tumor immune responses.
Anti-CTLA-4/CD152 Antibody
Anti-CTLA-4/CD152 Antibody
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Purity: 95%
Catalog No. T9901A-1254
Anti-CTLA-4/CD152 Antibody is a humanized monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4/CD152). This product specifically binds to the extracellular domain of CTLA-4, blocking its interaction with ligands CD80 (B7-1) and CD86 (B7-2). This blockade removes the negative regulatory signal of CTLA-4 on T-cell activation, thereby enhancing T-cell proliferation, cytokine production, and anti-tumor immune responses.
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Anti-CTLA-4/CD152 Antibody is a humanized monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4/CD152). This product specifically binds to the extracellular domain of CTLA-4, blocking its interaction with ligands CD80 (B7-1) and CD86 (B7-2). This blockade removes the negative regulatory signal of CTLA-4 on T-cell activation, thereby enhancing T-cell proliferation, cytokine production, and anti-tumor immune responses. |
| In vitro | Anti-CTLA-4/CD152 Antibody binds the CTLA-4 extracellular domain with high affinity. In T-cell assays, it reverses CD80/CD86-induced CTLA-4 inhibition, increasing IL-2 and IFN-γ production and restoring effector T-cell proliferation [1]. |
| In vivo | In preclinical tumor models, systemic administration of Anti-CTLA-4/CD152 Antibody leads to a reduction in tumor growth and a significant increase in the ratio of effector T cells to regulatory T cells (Tregs) within the tumor microenvironment; the treatment enhances the overall anti-tumor immune response by modulating the inhibitory checkpoints that normally limit T-cell activity during tumor progression [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CTLA-4/CD152 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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