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Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)
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Catalog No. TMAB-11306
Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) is a Rabbit antibody targeting Phospho-SMC1 alpha (Ser957). Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) can be used in ICC/IF, IF, IHC-Fr, IHC-P.
Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)
Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550)
😃Good
Catalog No. TMAB-11306
Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) is a Rabbit antibody targeting Phospho-SMC1 alpha (Ser957). Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) can be used in ICC/IF, IF, IHC-Fr, IHC-P.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) is a Rabbit antibody targeting Phospho-SMC1 alpha (Ser957). Anti-Phospho-SMC1 alpha (Ser957) Antibody (9G550) can be used in ICC/IF, IF, IHC-Fr, IHC-P. |
| Ig Type | IgG |
| Clone | 9G550 |
| Reactivity | Human,Rat,Mouse |
| Application | |
| Recommended Dose | ICC/IF=1:50-200; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesion complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesion complexes remain. At anaphase, the RAD21 subunit of the cohesion complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesion complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis |
| Tissue Specificity | The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. |
| Immunogen | A synthesized peptide: human SMC1 alpha around the phosphorylation site of S957 |
| Antigen Species | Human |
| Gene Name | SMC1A |
| Gene ID | |
| Protein Name | Structural maintenance of chromosomes protein 1A |
| Uniprot ID | |
| Function | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesion complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
| Molecular Weight | Theoretical: 143 kDa. Actual: 160 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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