Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA). It acts as a potent and selective agonist of the GABA B receptor.
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Description | 3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA). It acts as a potent and selective agonist of the GABA B receptor. |
In vitro | 3-Aminopropylphosphinic acid, at a concentration of 10 μM, exhibits a concentration-dependent reduction of cholinergic twitch contraction in the electrically stimulated ileum, demonstrating an IC50 value of 1.84-0.23 μM[2]. Additionally, this compound serves as an anti-aging agent for the skin[4]. |
In vivo | Administered intravenously at a dosage of 5 mg/kg, 3-Aminopropylphosphinic acid counteracts the inhibitory actions of GABA on vagal bronchospasm in guinea pigs. This finding underscores the compound's potential role in modulating GABA-related bronchial responses. |
Synonyms | 3-APPA, CGA147823, CGP27492 |
Molecular Weight | 123.092 |
Formula | C3H10NO2P |
CAS No. | 103680-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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3-Aminopropylphosphinic acid 103680-47-3 CGA 147823 3-APPA CGA147823 CGA-147823 CGP-27492 CGP27492 3 Aminopropylphosphinic acid CGP 27492 3Aminopropylphosphinic acid inhibitor inhibit