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Pim-1/2 kinase inhibitor 1

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Catalog No. T9229Cas No. 6320-51-0

Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].

Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1

😃Good
Purity: 99.78%
Catalog No. T9229Cas No. 6320-51-0
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$32-In Stock
10 mg$53-In Stock
25 mg$107-In Stock
50 mg$167-In Stock
100 mg$251-In Stock
200 mg$343-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.78%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
In vitro
Pim-1/2 kinase inhibitor 1 (compound D14) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM after 48 hours of incubation at varying concentrations [1].
Chemical Properties
Molecular Weight235.26
FormulaC11H9NO3S
Cas No.6320-51-0
SmilesCOc1ccc(C=C2SC(=O)NC2=O)cc1
Relative Density.1.391g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (212.53 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (10.63 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2506 mL21.2531 mL42.5062 mL212.5308 mL
5 mM0.8501 mL4.2506 mL8.5012 mL42.5062 mL
10 mM0.4251 mL2.1253 mL4.2506 mL21.2531 mL
20 mM0.2125 mL1.0627 mL2.1253 mL10.6265 mL
50 mM0.0850 mL0.4251 mL0.8501 mL4.2506 mL
100 mM0.0425 mL0.2125 mL0.4251 mL2.1253 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pim2Pim-1/2 kinase inhibitor 1Pim12,4Thiazolidinedione, 5pmethoxybenzylidene2,4 Thiazolidinedione, 5 p methoxybenzylidene
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