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Pim-1/2 kinase inhibitor 1

Name: Pim-1/2 kinase inhibitor 1
Brand: TargetMol
SKU: T9229
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9229Cas No. 6320-51-0

Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].

Pim-1/2 kinase inhibitor 1

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Purity: 99.78%

Catalog No. T9229Cas No. 6320-51-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	-	In Stock
10 mg	$53	-	In Stock
25 mg	$107	-	In Stock
50 mg	$167	-	In Stock
100 mg	$251	-	In Stock
200 mg	$343	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Appearance:Solid

Color:Cyan

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
In vitro	Pim-1/2 kinase inhibitor 1 (compound D14) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM after 48 hours of incubation at varying concentrations [1].

Chemical Properties

Molecular Weight	235.26
Formula	C₁₁H₉NO₃S
Cas No.	6320-51-0
Smiles	COc1ccc(C=C2SC(=O)NC2=O)cc1
Relative Density.	1.391g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (212.53 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (10.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2506 mL	21.2531 mL	42.5062 mL	212.5308 mL
5 mM	0.8501 mL	4.2506 mL	8.5012 mL	42.5062 mL
10 mM	0.4251 mL	2.1253 mL	4.2506 mL	21.2531 mL
20 mM	0.2125 mL	1.0627 mL	2.1253 mL	10.6265 mL
50 mM	0.0850 mL	0.4251 mL	0.8501 mL	4.2506 mL
100 mM	0.0425 mL	0.2125 mL	0.4251 mL	2.1253 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc