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α-Demethylnaproxen
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Catalog No. T7662Cas No. 23981-47-7
α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
α-Demethylnaproxen
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Purity: 97.57%
Catalog No. T7662Cas No. 23981-47-7
α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $30 | In Stock | In Stock | |
| 50 mg | $41 | In Stock | In Stock | |
| 100 mg | $68 | - | In Stock | |
| 200 mg | $100 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.57%
Appearance:Solid
Color:White
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Product Introduction
α-Demethylnaproxen AI Summary
α-Demethylnaproxen exhibits a range of bioactivities across various assays and biological systems. It inhibits the proliferation of HMVEC-L cells in vitro with a 5.0% inhibition of [3H]thymidine incorporation. The compound shows inhibitory activity against ovine cyclooxygenase-1 (COX-1) at 200 uM but is considered inactive in this assay as the inhibition was less than 50.0%. Notably, α-Demethylnaproxen inhibits Leukotriene LTC4 Synthase with an IC50 of 49660.0 nM and COX-1 with an IC50 of 4113.0 nM. Additionally, it inhibits mouse COX2-mediated 2-arachidonoylglycerol oxygenation with an IC50 of 1400.0 nM and arachidonic acid oxygenation at 10 uM with a 16.0% inhibition rate. It impacts various physiological markers, affecting liver and kidney function, metabolism, blood cell counts, electrolyte balance, and lipid levels. Furthermore, α-Demethylnaproxen inhibits human recombinant AKR1C3 with an IC50 of 650.0 nM, showing a higher selectivity for this enzyme over AKR1C2, which it inhibits with an IC50 of 19040.0 nM, resulting in a selectivity ratio of 29.0 for AKR1C2 to AKR1C3..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively) |
| Targets&IC50 | COX-1:21 Μm(ki), COX-2:19 μM(ki) |
| Molecular Weight | 216.23 |
| Formula | C13H12O3 |
| Cas No. | 23981-47-7 |
| Smiles | COc1ccc2cc(CC(O)=O)ccc2c1 |
| Relative Density. | 1.235 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.6 mg/mL (16.65 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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