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Ursolic acid

Name: Ursolic acid
Brand: TargetMol
SKU: T0722
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0722Cas No. 77-52-1

Alias Urson, Prunol, NSC-4060, NSC 167406, Malol

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Ursolic acid

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Purity: 99.81%

Catalog No. T0722Alias Urson, Prunol, NSC-4060, NSC 167406, MalolCas No. 77-52-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$83	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.
Targets&IC50	A375 cells:30.88 μM, A549 cells:11.4 μM, Bel-7402 cells:64.64 μM, CAPAN-1 cells:8.6 μM, AGS cells:20.6 μM, Bcap37 cells:28.69 μM, B16 cells:3.1 μM, Ca9-22 cells:5.9 μg/mL, ASPC1 cells:12.6 μM, 4T1 cells:44.08 μM, WI-38 cells:1.8 μM, BGC-823 cells:> 10 μM, B16 F10 cells:20.08 μM, THP-1 cells:9.1 μM, T24 cells:29.29 μM
In vitro	METHODS: Embryonal carcinoma cells NTERA-2 and NCCIT were treated with Ursolic acid (1-50 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Concentration-dependent inhibition of NTERA-2 and NCCIT cell viability by Ursolic acid treatment. [1] METHODS: Lung cancer cells H460 and H1975 were treated with Ursolic acid (5-20 nM) for 48 h. Apoptosis was detected by Flow cytometry. RESULTS: Ursolic acid significantly increased the percentage of Annexin V (+) apoptotic cells compared to control. [2]
In vivo	METHODS: To investigate the antidepressant-like effects, Ursolic acid (0.001-10 mg/kg, distilled water with 10% Tween 80) was orally administered to Swiss mice, and the TST, FST, or open-field test was performed 60 min later. RESULTS: Ursolic acid shortened the immobilization time in TST and FST.The antidepressant-like effect of Ursolic acid in TST may be mediated by the activation of dopamine D1 and D2 receptors interacting with the dopaminergic system. [3]
Synonyms	Urson, Prunol, NSC-4060, NSC 167406, Malol

Chemical Properties

Molecular Weight	456.7
Formula	C₃₀H₄₈O₃
Cas No.	77-52-1
Smiles	C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Relative Density.	1.09 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Propylene glycol: 4.76 mg/mL (10.42 mM), Sonication is recommended.

DMSO: 50 mg/mL (109.48 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.47 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Propylene glycol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	109.4811 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	21.8962 mL
10 mM	0.2190 mL	1.0948 mL	2.1896 mL	10.9481 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1095 mL	0.5474 mL	1.0948 mL	5.4741 mL
50 mM	0.0438 mL	0.2190 mL	0.4379 mL	2.1896 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc