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TNCA
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Catalog No. T7716Cas No. 42438-90-4
Alias Lycoperodine-1
TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.
TNCA
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Purity: 97.73%
Catalog No. T7716Alias Lycoperodine-1Cas No. 42438-90-4
TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $31 | In Stock | In Stock | |
| 25 mg | $52 | In Stock | In Stock | |
| 50 mg | $81 | In Stock | In Stock | |
| 100 mg | $123 | In Stock | In Stock | |
| 500 mg | $297 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.73%
Appearance:Solid
Color:White to Red
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Product Introduction
TNCA AI Summary
TNCA displays notable bioactivity across several domains, primarily showing significant inhibitory effects on platelet aggregation and thrombus formation. In vitro studies using rabbit blood reveal that it notably affects platelet aggregation induced by adenosine diphosphate (ADP) and platelet activating factor (PAF) at varying doses. This compound also impacts the adhesion of high pulmonary metastatic SACC-LM cells and platelets, alongside reducing wet and dry thrombus weights in male Wistar anesthetized rats.
Furthermore, in pig blood assays, TNCA demonstrates inhibitory activity on several platelet aggregation pathways, with IC50 values approximate to 3300 nM for ADP, arachidonic acid, PAF, and thrombin-induced platelet aggregation, suggesting potential as an antiplatelet agent. It exhibits effective antithrombotic activity in the Wistar rat arteriovenous cannula model, reducing thrombus weight at a dose of 5 umol/kg, iv.
Beyond its antiplatelet properties, TNCA also shows anti-inflammatory potential by inhibiting iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells and TNF-alpha-induced NFkappaB activation in human HEK293 cells. It enhances quinone reductase 1 activity in mouse Hepa-1c1c7 cells and inhibits aromatase activity, reflecting potential cytoprotective and enzyme inhibitory functions. Additionally, its antioxidant capability is indicated by a trolox equivalents ratio of 1.68 in the ABTS radical scavenging assay.
Overall, the multifaceted bioactivity profile of TNCA suggests significant therapeutic potential across antiplatelet, antithrombotic, anti-inflammatory, cytoprotective, and antioxidant domains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity. |
| Synonyms | Lycoperodine-1 |
| Molecular Weight | 216.24 |
| Formula | C12H12N2O2 |
| Cas No. | 42438-90-4 |
| Smiles | OC(=O)[C@@H]1Cc2c(CN1)[nH]c1ccccc21 |
| Relative Density. | 1.377g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: < 2.16 mg/mL (10 mM, insoluble or slightly soluble)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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