Shopping Cart

Remove All
Your shopping cart is currently empty

Src Inhibitor 3

Name: Src Inhibitor 3
Brand: TargetMol
SKU: T13000
Price: 738 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13000Cas No. 2380027-49-4

Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferation induced by T cell receptor signaling.

Src Inhibitor 3

🥰Excellent

Purity: 98.35%

Catalog No. T13000Cas No. 2380027-49-4

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$196	In Stock
10 mg	$337	In Stock
25 mg	$534	In Stock
50 mg	$738	In Stock
100 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$293	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:98.35%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferation induced by T cell receptor signaling.
Targets&IC50	c-Src (caliper assay):4 nM , c-Src (CSK HTRF assay):<3 nM
In vivo	Src Inhibitor 3 (oral) reduces inhibitory LCK phosphorylation in vivo and shows the ability to enhance T cell activation in response to antigen stimulation[1].

Chemical Properties

Molecular Weight	671.12
Formula	C₃₄H₃₂ClFN₈O₄
Cas No.	2380027-49-4
Smiles	COc1ccc2c(cnn2c1)C(=O)Nc1ccc(NC(=O)c2nn(C3CCN(CC3)C(=O)CC(C)(C)C#N)c3ccc(F)cc23)cc1Cl
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (141.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4900 mL	7.4502 mL	14.9005 mL	74.5023 mL
5 mM	0.2980 mL	1.4900 mL	2.9801 mL	14.9005 mL
10 mM	0.1490 mL	0.7450 mL	1.4900 mL	7.4502 mL
20 mM	0.0745 mL	0.3725 mL	0.7450 mL	3.7251 mL
50 mM	0.0298 mL	0.1490 mL	0.2980 mL	1.4900 mL
100 mM	0.0149 mL	0.0745 mL	0.1490 mL	0.7450 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc