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Anti-TrkA Antibody (1W212) (Synonyms: neurotrophic tyrosine kinase, receptor, type 1)
Catalog No. TMAY-01595 Copy Product Info
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Anti-TrkA Antibody (1W212) is a Rabbit antibody targeting TrkA. Anti-TrkA Antibody (1W212) can be used in IHC-P.
Anti-TrkA Antibody (1W212)
Copy Product Info🥰Excellent
Catalog No. TMAY-01595
Synonyms neurotrophic tyrosine kinase, receptor, type 1
Anti-TrkA Antibody (1W212) is a Rabbit antibody targeting TrkA. Anti-TrkA Antibody (1W212) can be used in IHC-P.
Anti-TrkA Antibody
(1W212)
(1W212)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $269 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-TrkA Antibody (1W212) is a Rabbit antibody targeting TrkA. Anti-TrkA Antibody (1W212) can be used in IHC-P. |
| Synonyms | neurotrophic tyrosine kinase, receptor, type 1 |
| Ig Type | Rabbit IgG |
| Clone | 1W212 |
| Reactivity | Human |
| Specificity | Human TrkA |
| Verified Activity | Immunochemical staining of human NTRK1 in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). |
| Application | |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TrkA / NTRK1 (rh TrkA / NTRK1; TMPY-01084; NP_002520.2; Met 1-Pro 382). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding tonerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as the establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human TrkA / NTRK1 protein (TMPY-01084) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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