Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
😃Good
Catalog No. TMAH-00957
Alias Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB1 (p-Ser807), RB1 (p-S807), RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, p-RB1 (Ser807), p-RB1 (S807), pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop
Anti-Phospho-RB1 (Ser807) Antibody (6Y72) is an antibody targeting Phospho-RB1 (Ser807). Anti-Phospho-RB1 (Ser807) Antibody (6Y72) can be used in ELISA, IF.
Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
😃Good
Catalog No. TMAH-00957Alias Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB1 (p-Ser807), RB1 (p-S807), RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, p-RB1 (Ser807), p-RB1 (S807), pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop
Anti-Phospho-RB1 (Ser807) Antibody (6Y72) is an antibody targeting Phospho-RB1 (Ser807). Anti-Phospho-RB1 (Ser807) Antibody (6Y72) can be used in ELISA, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IF Reactivity: Human |
| Alias | Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB1 (p-Ser807), RB1 (p-S807), RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, p-RB1 (Ser807), p-RB1 (S807), pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop |
| Ig Type | Rabbit IgG |
| Clone | 6Y72 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of K562 cells with TMAH-00957 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IF |
| Recommended Dose | IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-RB1 (S807) |
| Antigen Species | Human |
| Gene ID | 5925 |
| Uniprot ID | |
| Biology Area | Cell Biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-Phospho-RB1 (Ser807) Antibody (6Y72) | purchase Anti-Phospho-RB1 (Ser807) Antibody (6Y72) | Anti-Phospho-RB1 (Ser807) Antibody (6Y72) cost | order Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.