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Limonene

Name: Limonene
Brand: TargetMol
SKU: T75431
Rating: 4.5 (1 reviews)

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Catalog No. T75431Cas No. 138-86-3

Alias Dipentene, (±)-α-Limonene, (±)-Limonene

Limonene (Dipentene) is a monoterpene found in citrus plants such as lemon, orange, and grape, widely used in cosmetics and household products as a fragrance, with antimicrobial, antiproliferative, antioxidant, and anti-inflammatory properties.

Limonene

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Catalog No. T75431Alias Dipentene, (±)-α-Limonene, (±)-LimoneneCas No. 138-86-3

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Product Introduction

Bioactivity

Description	Limonene (Dipentene) is a monoterpene found in citrus plants such as lemon, orange, and grape, widely used in cosmetics and household products as a fragrance, with antimicrobial, antiproliferative, antioxidant, and anti-inflammatory properties.
In vitro	Limonene exerts anti-inflammatory effects by reducing pro-inflammatory cytokines (TNF-α, IL-1β, COX-2), inhibiting TLR4/NF-κB/AP-1 but not the IRF3 signaling pathway, and regulating oxidative stress through Nrf2 activation. [1] Limonene treatment inhibits UVB-induced α-MSH secretion and then suppresses melanocortin (POMC) by inhibiting p53 transcriptional activation. [2]
In vivo	Limonene (100 and 200 mg/kg, orally administered) in LPS mouse models mitigated the decline in renal function due to LPS induction, resulting in reduced serum urea and creatinine levels in mice. [1] Limonene (20 mg/kg, intrabitoneally administered) reduced serum and brain nitrite levels and decreased the expression of IL-1β and TNF-α in the hippocampus of MS-stressed mice. [3]
Synonyms	Dipentene, (±)-α-Limonene, (±)-Limonene

Chemical Properties

Molecular Weight	136.23
Formula	C₁₀H₁₆
Cas No.	138-86-3
Smiles	C=C(C)C1CC=C(C)CC1

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 80 mg/mL (587.24 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	7.3405 mL	36.7026 mL	73.4053 mL	367.0264 mL
5 mM	1.4681 mL	7.3405 mL	14.6811 mL	73.4053 mL
10 mM	0.7341 mL	3.6703 mL	7.3405 mL	36.7026 mL
20 mM	0.3670 mL	1.8351 mL	3.6703 mL	18.3513 mL
50 mM	0.1468 mL	0.7341 mL	1.4681 mL	7.3405 mL
100 mM	0.0734 mL	0.3670 mL	0.7341 mL	3.6703 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc