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Ro 25-6981 Maleate

Name: Ro 25-6981 Maleate
Brand: TargetMol
SKU: T12758L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12758LCas No. 1312991-76-6

Alias Ro-25-6981 Maleate, Ro 256981 Maleate

Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).

Ro 25-6981 Maleate

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Purity: 99.42%

Catalog No. T12758LAlias Ro-25-6981 Maleate, Ro 256981 MaleateCas No. 1312991-76-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$78	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$229	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$745	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).
In vivo	In 6-OHDA-lesioned rats, Ro 25-6981 Maleate (0.39-12.5 mg/kg; intraperitoneal injection) dose-dependently induces contralateral tight nose-to-tail rotations and elicits a weak ipsilateral circling response, indicating a mild nonspecific stimulatory action of the compound[1].
Synonyms	Ro-25-6981 Maleate, Ro 256981 Maleate

Chemical Properties

Molecular Weight	455.54
Formula	C₂₆H₃₃NO₆
Cas No.	1312991-76-6
Smiles	OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (8.78 mM), Sonication is recommended.

DMSO: 61 mg/mL (133.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1952 mL	10.9760 mL	21.9520 mL	109.7598 mL
5 mM	0.4390 mL	2.1952 mL	4.3904 mL	21.9520 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2195 mL	1.0976 mL	2.1952 mL	10.9760 mL
20 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4880 mL
50 mM	0.0439 mL	0.2195 mL	0.4390 mL	2.1952 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc