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Ro 25-6981 Maleate

Name: Ro 25-6981 Maleate
Brand: TargetMol
SKU: T12758L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12758LCas No. 1312991-76-6

Alias Ro-25-6981 Maleate, Ro 256981 Maleate

Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).

Ro 25-6981 Maleate

🥰Excellent

Purity: 99.42%

Catalog No. T12758LAlias Ro-25-6981 Maleate, Ro 256981 MaleateCas No. 1312991-76-6

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$82	In Stock
10 mg	$118	In Stock
25 mg	$239	In Stock
50 mg	$416	In Stock
100 mg	$782	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Batch Information

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Purity:99.42%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).
In vivo	In 6-OHDA-lesioned rats, Ro 25-6981 Maleate (0.39-12.5 mg/kg; intraperitoneal injection) dose-dependently induces contralateral tight nose-to-tail rotations and elicits a weak ipsilateral circling response, indicating a mild nonspecific stimulatory action of the compound[1].
Synonyms	Ro-25-6981 Maleate, Ro 256981 Maleate

Chemical Properties

Molecular Weight	455.54
Formula	C₂₆H₃₃NO₆
Cas No.	1312991-76-6
Smiles	OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (8.78 mM), Sonication is recommended.

DMSO: 61 mg/mL (133.91 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1952 mL	10.9760 mL	21.9520 mL	109.7598 mL
5 mM	0.4390 mL	2.1952 mL	4.3904 mL	21.9520 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2195 mL	1.0976 mL	2.1952 mL	10.9760 mL
20 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4880 mL
50 mM	0.0439 mL	0.2195 mL	0.4390 mL	2.1952 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc