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CEP-9722
🥰Excellent
Catalog No. T62196Cas No. 916574-83-9
Alias CK-102, CK102, CEP9722
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
CEP-9722
🥰Excellent
Purity: 98.56%
Catalog No. T62196Alias CK-102, CK102, CEP9722Cas No. 916574-83-9
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $462 | In Stock | |
| 5 mg | $1,070 | In Stock | |
| 10 mg | $1,430 | In Stock | |
| 25 mg | $2,130 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.56%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer. |
| Targets&IC50 | PARP1:20 nM, PARP2:6 nM |
| In vitro | CEP-9722, the precursor drug of CEP-8983, is a selectively orally active inhibitor of PARP-1 and PARP-2, with IC50s of 20 nM and 6 nM for both, respectively.[2] |
| In vivo | In the RT4 xenograft model, CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; 5 days per week for 4 weeks) showed dose-dependent antitumor effects; 200 mg/kg/day was significantly superior to the control, while 100 mg/kg did not show significantly better efficacy than the control. [1] |
| Synonyms | CK-102, CK102, CEP9722 |
| Molecular Weight | 418.49 |
| Formula | C24H26N4O3 |
| Cas No. | 916574-83-9 |
| Smiles | O=C1C2=C3C(NC=4C=CC=C(OC)C43)=C5C(=C2C(=O)N1CN6CCN(C)CC6)CCC5 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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