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CEP-9722
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Catalog No. T62196Cas No. 916574-83-9
Alias CK-102, CK102, CEP9722
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
CEP-9722
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Purity: 98.56%
Catalog No. T62196Alias CK-102, CK102, CEP9722Cas No. 916574-83-9
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $462 | In Stock | In Stock | |
| 5 mg | $1,070 | In Stock | In Stock | |
| 10 mg | $1,430 | In Stock | In Stock | |
| 25 mg | $2,130 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.56%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer. |
| Targets&IC50 | PARP2:6 nM, PARP1:20 nM |
| In vitro | CEP-9722, the precursor drug of CEP-8983, is a selectively orally active inhibitor of PARP-1 and PARP-2, with IC50s of 20 nM and 6 nM for both, respectively.[2] |
| In vivo | In the RT4 xenograft model, CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; 5 days per week for 4 weeks) showed dose-dependent antitumor effects; 200 mg/kg/day was significantly superior to the control, while 100 mg/kg did not show significantly better efficacy than the control. [1] |
| Synonyms | CK-102, CK102, CEP9722 |
| Molecular Weight | 418.49 |
| Formula | C24H26N4O3 |
| Cas No. | 916574-83-9 |
| Smiles | O=C1C2=C3C(NC=4C=CC=C(OC)C43)=C5C(=C2C(=O)N1CN6CCN(C)CC6)CCC5 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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