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DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Catalog No. TMPY-05760
Synonyms: TRAMP, tumor necrosis factor receptor superfamily, member 25, TR3, DDR3, TNFRSF12, APO-3, WSL-LR, DR3, WSL-1, LARD

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.

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DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 306.00
100 μg 5 days $ 726.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q93038-10
Synonyms TRAMP, tumor necrosis factor receptor superfamily, member 25, TR3, DDR3, TNFRSF12, APO-3, WSL-LR, DR3, WSL-1, LARD
Construction The Human TNFRSF25 (NP_683867.1) (Met1-Gln199) was expressed with the Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight 45.9 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

References and Literature

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Keywords

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP TR-3 WSL1 tumor necrosis factor receptor superfamily, member 25 TR3 APO3 DDR3 TNFRSF12 APO 3 APO-3 WSL-LR DR3 TNFRSF-12 WSL-1 DDR 3 WSL 1 DR-3 TNFRSF 12 TR 3 LARD DDR-3 DR 3 recombinant recombinant-proteins proteins protein

 

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