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ribosome

Ribosomes are macromolecular machines, found within all living cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the translational apparatus.

  • Doxycycline
    T1687564-25-0
    Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
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  • Puromycin dihydrochloride
    T221958-58-2
    Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
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  • Neomycin sulfate
    T09501405-10-3
    Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert antimicrobial activity. Neomycin sulfate is commonly used to screen prokaryotic and eukaryotic cells for Neo resistance genes.
    • $43
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  • Demeclocycline hydrochloride
    T140064-73-3
    Demeclocycline hydrochloride (Declomycin) is a TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.
    • $30
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  • Hygromycin B
    T102231282-04-9
    Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic or eukaryotic cells transfected with hph or hyg resistance genes.
    • $48
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  • Kanamycin sulfate
    T079325389-94-0
    Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside bacteriocidal antibiotic.
    • $41
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  • Tetracycline
    T0912L60-54-8
    Tetracycline (Tetracyclin) is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
    • $77
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  • Gentamicin sulfate
    T13261405-41-0
    Gentamicin sulfate (SCH9724) is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
    • $31
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  • Streptomycin sulfate
    T00603810-74-0
    Streptomycin sulfate (Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
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  • Omadacycline
    T5189389139-89-3
    Omadacycline (Amadacycline), a new tetracycline antibiotic, can inhibit the 30s subunit of bacterial ribosome.
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  • Oxytetracycline
    T089579-57-2
    Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
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  • Kanamycin A
    T0793L59-01-8
    Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin is an aminoglycoside bacteriocidal antibiotic and used to treat a wide variety of infections. Kanamycin interacts with the
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  • KKL-10
    T4222952849-76-2
    KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria.
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  • Amikacin
    T101337517-28-5
    Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin.
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  • Spectinomycin dihydrochloride pentahydrate
    T0788L22189-32-8
    Spectinomycin dihydrochloride pentahydrate (Spectogard) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
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  • Erythromycin
    T1032114-07-8
    Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.
    • $46
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  • Clarithromycin
    T143481103-11-9
    Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
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  • Chlortetracycline hydrochloride
    T130464-72-2
    Chlortetracycline Hydrochloride is a tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride (Isphamycin) is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative organisms, spirochetes, rickettsial species, certain protozoa and Mycoplasma and Chlamydia organisms.
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  • Tetracycline hydrochloride
    T091264-75-5
    Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
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  • Capreomycin sulfate
    T14411405-37-4
    Capreomycin sulfate (Capastat sulfate) , a cyclic peptide antibiotic, binds to the 70S ribosomal unit leading to inhibition of protein synthesis.
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  • Tigecycline
    T1569220620-09-7
    Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.
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  • Methacycline hydrochloride
    T05183963-95-9
    Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
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  • Lincomycin hydrochloride monohydrate
    T12357179-49-9
    Lincomycin hydrochloride monohydrate (Lincomycin hydrochloride hydrate) is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
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  • Spectinomycin dihydrochloride
    T078821736-83-4
    Spectinomycin dihydrochloride (Actinospectacin) is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
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  • Azithromycin hydrate
    T1419117772-70-0
    Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
    • $36
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  • Retapamulin
    T6638224452-66-8
    Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).
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  • Chloramphenicol
    T120556-75-7
    Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
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  • Erythromycin ethylsuccinate
    T04741264-62-6
    Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.
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  • Kanamycin
    T649228063-07-8
    Kanamycin is an aminoglycoside bacteriocidal antibiotic.
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    • Clindamycin phosphate
      T114224729-96-2
      Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate (Clindamycin 2-dihydrogen phosphate) is used in topical preparations.
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    • Doxycycline (hyclate)
      T1687L24390-14-5
      Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor activity.
      • $41
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    • Lefamulin acetate
      T118361350636-82-6
      Lefamulin acetate (BC-3781 acetate) (formally BC-3781 acetate) is a novel pleuromutilin antibiotic and is the first to be used for the systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer. Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment.
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    • Acetylspiramycin
      T155724916-51-6
      Acetylspiramycin (Spiramycin B) targets 50S ribosome to inhibit protein synthesis.
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    • Lincomycin hydrochloride
      T1277859-18-7
      Lincomycin hydrochloride (U10149A) is a lincosamide antibiotic identified in S.lincolnensis with activity against gram-positive cocci and anaerobic bacteria.
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    • Tobramycin
      T125532986-56-4
      Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.
      • $33
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    • Amikacin sulfate
      T3125149022-22-0
      Amikacin sulfate is a broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and ototoxic like the other aminoglycoside antibiotics.
      • $30
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    • Dirithromycin
      T097162013-04-1
      Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.
      • $33
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    • Roxithromycin
      T115180214-83-1
      Roxithromycin (RU-28965) is a semi-synthetic derivative of the macrolide antibiotic erythromycin with antibacterial and anti-malarial activities.
      • $50
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