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Proteases/Proteasome Proteases/ProteasomeProtease
A protease (also called a peptidase or proteinase) is an enzyme that catalyzes (increases reaction rate or "speeds up") proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks bonds. Proteases are involved in many biological functions, including digestion of ingested proteins, protein catabolism (breakdown of old proteins), and cell signaling.
DMNT
4,8-dimethylnona-1,3,7-triene
T6916051911-82-1
DMNT is a naturally occurring homoterpene, a volatile organic compounds (VOCs) released by plants through a defense response that induces defensive Sporamin protease inhibitor activity in neighboring plants thereby warding off pests.
- $293
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PTBP1-RNA-binding inhibitor P6 TFA
PTBP1 α3-helix derived peptide P6 TFA
T81356
PTBP1-RNA-binding inhibitor P6 TFA (PTBP1 α3-helix derived peptide P6 TFA) is a specific stapled peptide inhibitor of the splicing factor PTBP1, which is used to inhibit RNA alternative splicing events regulated by PTBP1. PTBP1-RNA-binding inhibitor P6 TFA exerts its effects by binding to the RNA recognition motif of PTBP1.
- $157
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Hinokiflavone
Cited
T4S018119202-36-9
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO protease inhibitor by impeding the activity of sentrin-specific protease 1 (SENP1). Hinokiflavone also demonstrates significant cytotoxicity, including the inhibition of MMP-9.
- $38
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CitedLactacystin
T15702133343-34-7
Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models.
- $123
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Ono-3307 mesylate
Ono-3307, Ono3307, Ono 3307
T2824876472-29-2In house
Ono-3307 mesylate is a protease inhibitor with inhibitory effects on a variety of proteases.Ono-3307 mesylate has significant protective effects against liver injury in rats and inhibits the deposition of radiofibrillar proteins in the kidneys and lungs.PF-184298 is a protease inhibitor with potential antioxidant effects in plasma and adipose tissue.PF-184298 can be used in the study of pancreatitis.
- $293
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(3R,4R)-A2-32-01
T101251359752-95-6
(3R,4R)-A2-32-01 is the (R,R)-enantiomer of A2-32-01 and has potential antibacterial activity.
- $199
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EDTA, Disodium Salt, Dihydrate
Ethylenediaminetetraacetic acid disodium dihydrate
T661556381-92-6
EDTA, Disodium Salt, Dihydrate (Ethylenediaminetetraacetic acid disodium dihydrate) is a metal ion chelator used as a protease inhibitor.EDTA, Disodium Salt, Dihydrate is a molecule that is ineffective against cellulase activity and is widely used in protein purification.EDTA, Disodium Salt, Dihydrate promotes the excretion of cellulase by binding to the metals and promotes their excretion.
- $39
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ADAMTS-5-IN-3
T622822688733-96-0
ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.
- $2,270
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ADAMTS-5 Inhibitor
T14124929634-33-3
ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis.
- $40
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Aldumastat
S201086, GLPG1972, G504572
T358591957278-93-1
Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.
- $299
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Antipain dihydrochloride
BDBM-32804, BDBM32804, BDBM 32804, Antipain, Antipain 2HCl
T2663737682-72-7
Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.
- $69
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TR-107
Anticancer agent 230
T853102485052-87-5
TR-107 (Anticancer agent 230) is a selective and potent activator of the mitochondrial protease ClpP that inhibits tumor growth in the MDA-MB-231 xenograft model.
- $40
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Patamostat HCl
Patamostat HCl(114568-26-2 Free base)
T9670L3031765-17-7In house
Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.
- $195
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(Rac)-Telmesteine
3-ethoxycarbonyl-1,3-thiazolidine-4-carboxylic acid, 3,4-Thiazolidinedicarboxylic Acid 3-Ethyl Ester, 3-(Ethoxycarbonyl)thiazolidine-4-carboxylic acid
T12678127657-29-8
(Rac)-Telmesteine (3,4-Thiazolidinedicarboxylic Acid 3-Ethyl Ester) is an inhibitor of protease and is thus a suitable enzyme stabilizer.
- $29
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TS-24
TS24, TS 24
T853111563260-97-8
TS-24 is an inhibitor of the cysteine protease histatin S (CTSS).TS-24 promotes BRCA1-mediated apoptosis and shows radiosensitization in a TNBC xenograft mouse model.
- $63
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ZG36
T80737
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrial dysfunction and inducing leukemic cell death. Additionally, it inhibits the development of acute myeloid leukemia in a xenograft mouse model [1].
- Inquiry Price
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(S)-ZG197
T73315
(S)-ZG197 is a compound that acts as a highly selective activator of the Staphylococcus aureus Caseinolytic Protease P (Sa ClpP), demonstrating efficacy at a concentration of 1.4 μM (EC50).
- $2,570
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ADAMTS-5-IN-2
T72868294648-66-1
ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 µM, and holds potential for osteoarthritis research.
- $1,520
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Z-GGF-CMK
T8010135172-59-9
Z-GGF-CMK, a protease inhibitor, impedes ClpP1P2 and proteasome activity and demonstrates cytotoxic effects on HepG2 cells, with a CC50 value of 125 μM [1].
- Inquiry Price
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(3S,4S)-A2-32-01
T72657
(3S,4S)-A2-32-01, a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .
- $1,430
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(R)-ZG197
T73314
(R)-ZG197 is a compound that acts as a highly selective activator for Staphylococcus aureus Caseinolytic protease P (Sa ClpP), exhibiting an effective concentration (EC50) of 1.5 μM. It also activates Homo sapiens ClpP (Hs ClpP) with an EC50 of 31.4 μM.
- $2,570
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