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SCH 563705

Name: SCH 563705
Brand: TargetMol
SKU: T16864
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16864Cas No. 473728-58-4

SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.

SCH 563705

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Purity: 98.03%

Catalog No. T16864Cas No. 473728-58-4

SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$313	-	In Stock
5 mg	$653	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,490	-	In Stock
50 mg	$1,990	-	In Stock
1 mL x 10 mM (in DMSO)	$719	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.03%

Appearance:Solid

Color:Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.
Targets&IC50	CXCR2:1 nM (ki), CXCR2:1.3 nM, CXCR1:7.3 nM, CXCR1:3 nM (ki), CXCR2 (mouse):5.2 nM
In vitro	SCH 563705 is a potent oral CXCR2 and CXCR1 antagonist with IC50 values of CXCR2 IC50=1.3 nM, CXCR1 IC50=7.3 nM, and Ki values of CXCR2 Ki=1 nM and CXCR1 Ki=3 nM, respectively.SCH 563705 potently inhibits Gro-a and IL-8 induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). SCH 563705 effectively inhibited Gro-a and IL-8-induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). [1] SCH 563705 effectively inhibits mouse CXCR2 (IC50 = 5.2 nM). [2]
In vivo	SCH 563705 has a favorable oral pharmacokinetic profile in rats, mice, monkeys and dogs. [1] Oral administration of 50 mg/kg SCH 563705 to BALB/c female mice decreased the frequency of Ly6G+ Ly6C+ neutrophils in the blood and maintained the level of Ly6GLy6C hi monocytes. [2]

Chemical Properties

Molecular Weight	425.48
Formula	C₂₃H₂₇N₃O₅
Cas No.	473728-58-4
Smiles	N(C1=C(N[C@H](CC)C2=CC(C(C)C)=CO2)C(=O)C1=O)C3=C(O)C(C(N(C)C)=O)=CC=C3
Relative Density.	1.29g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (235.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7514 mL	23.5029 mL	117.5143 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL	23.5029 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL	11.7514 mL
20 mM	0.1175 mL	0.5876 mL	1.1751 mL	5.8757 mL
50 mM	0.0470 mL	0.2350 mL	0.4701 mL	2.3503 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc