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SCH 563705

Name: SCH 563705
Brand: TargetMol
SKU: T16864
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16864Cas No. 473728-58-4

SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.

SCH 563705

🥰Excellent

Purity: 98.03%

Catalog No. T16864Cas No. 473728-58-4

SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$313	-	In Stock
5 mg	$653	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,730	-	In Stock
50 mg	$2,350	-	In Stock
1 mL x 10 mM (in DMSO)	$719	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.03%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.
Targets&IC50	CXCR2:1.3 nM, CXCR2 (mouse):5.2 nM, CXCR1:7.3 nM, CXCR1:3 nM (ki), CXCR2:1 nM (ki)
In vitro	SCH 563705 is a potent oral CXCR2 and CXCR1 antagonist with IC50 values of CXCR2 IC50=1.3 nM, CXCR1 IC50=7.3 nM, and Ki values of CXCR2 Ki=1 nM and CXCR1 Ki=3 nM, respectively.SCH 563705 potently inhibits Gro-a and IL-8 induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). SCH 563705 effectively inhibited Gro-a and IL-8-induced human neutrophil migration (CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM). [1] SCH 563705 effectively inhibits mouse CXCR2 (IC50 = 5.2 nM). [2]
In vivo	SCH 563705 has a favorable oral pharmacokinetic profile in rats, mice, monkeys and dogs. [1] Oral administration of 50 mg/kg SCH 563705 to BALB/c female mice decreased the frequency of Ly6G+ Ly6C+ neutrophils in the blood and maintained the level of Ly6GLy6C hi monocytes. [2]

Chemical Properties

Molecular Weight	425.48
Formula	C₂₃H₂₇N₃O₅
Cas No.	473728-58-4
Smiles	N(C1=C(N[C@H](CC)C2=CC(C(C)C)=CO2)C(=O)C1=O)C3=C(O)C(C(N(C)C)=O)=CC=C3
Relative Density.	1.29g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (235.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7514 mL	23.5029 mL	117.5143 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL	23.5029 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL	11.7514 mL
20 mM	0.1175 mL	0.5876 mL	1.1751 mL	5.8757 mL
50 mM	0.0470 mL	0.2350 mL	0.4701 mL	2.3503 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc