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Prinomastat hydrochloride

Name: Prinomastat hydrochloride
Brand: TargetMol
SKU: T12539
Rating: 4.5 (1 reviews)

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Catalog No. T12539Cas No. 1435779-45-5

Alias KB-R9896 hydrochloride, AG3340 hydrochloride

Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.

Prinomastat hydrochloride

😃Good

Catalog No. T12539Alias KB-R9896 hydrochloride, AG3340 hydrochlorideCas No. 1435779-45-5

Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.

Pack Size	Price	Availability
25 mg	$1,070	1-2 weeks
50 mg	$1,390	1-2 weeks
100 mg	$2,120	1-2 weeks

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Product Introduction

Bioactivity

Description	Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.
Targets&IC50	MMP2:0.05 nM (Ki), MMP9:5 nM, MMP9:0.26 nM (Ki), MMP13:0.3 nM (Ki), MMP13:6.3 nM, Collagenases 1:0.03 nM (Ki), MMP1:79 nM
In vitro	Prinomastat inhibits Wnt1-induced MMP-3 production. Reversal of Wnt1-induced EMT and β-catenin transcriptional activity by Prinomastat[1].
In vivo	Prinomastat has good tumour growth inhibition, with a short T1/2 of 1.6 hours[1].
Synonyms	KB-R9896 hydrochloride, AG3340 hydrochloride

Chemical Properties

Molecular Weight	459.97
Formula	C₁₈H₂₂ClN₃O₅S₂
Cas No.	1435779-45-5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (217.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1741 mL	10.8703 mL	21.7405 mL	108.7027 mL
5 mM	0.4348 mL	2.1741 mL	4.3481 mL	21.7405 mL
10 mM	0.2174 mL	1.0870 mL	2.1741 mL	10.8703 mL
20 mM	0.1087 mL	0.5435 mL	1.0870 mL	5.4351 mL
50 mM	0.0435 mL	0.2174 mL	0.4348 mL	2.1741 mL
100 mM	0.0217 mL	0.1087 mL	0.2174 mL	1.0870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc