CCL5 Protein, Human, Recombinant (HEK293)

Name: CCL5 Protein, Human, Recombinant (HEK293)
Brand: TargetMol
SKU: TMPS-00121
Rating: 4.5 (1 reviews)

(Synonyms: TCP228, SIS-delta, SISd, SCYA5, RANTES, eoCP, D17S136E, CCL-5, C-C motif chemokine ligand 5) Copy Product Info

Synonyms: TCP228, SIS-delta, SISd, SCYA5, RANTES, eoCP, D17S136E, CCL-5, C-C motif chemokine ligand 5

Catalog No. TMPS-00121 Copy Product Info

CCL5 Protein, Human, Recombinant (HEK293) is expressed in HEK293 Cells. The accession number is P13501.

Pack Size	Price	USA Stock	Global Stock
5 µg	$85	7-10 days	7-10 days
10 µg	$113	7-10 days	7-10 days
25 µg	$170	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:> 98% as determined by SDS-PAGE

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	The EC 50 value of human RANTES/CCL5 on Ca 2+ mobilization assay in CHO-K1/Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.2 μg/ml.
Description	CCL5 Protein, Human, Recombinant (HEK293) is expressed in HEK293 Cells. The accession number is P13501.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P13501
Construction	Ser24-Ser91
Protein Purity	> 98% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	TCP228, SIS-delta, SISd, SCYA5, RANTES, eoCP, D17S136E, CCL-5, C-C motif chemokine ligand 5
Research Background	Chemokine (C-C motif) ligand 5(CCL5), also known as RANTES (Regulated upon activation, Normal T cell Expressed and presumable Secreted) is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. RANTES is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes in inflammatory sites. With the help of specific cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, RANTES induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. RANTES is also an HIV-suppressive factor released from CD8 + T cells. This chemokine has been localized to chromosome 17 in humans. It has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV).

Chemical Properties

Molecular Weight

~8 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.