ALOX5 stabilizer-1

Name: ALOX5 stabilizer-1
Brand: TargetMol
SKU: T213115
Rating: 4.5 (1 reviews)

Catalog No. T213115 Copy Product Info

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ALOX5 stabilizer-1 is an inhibitor of arachidonic acid 5-lipoxygenase (ALOX5) with a Kd value of 7.26 μM. It reduces protein levels of β-catenin and subsequently inhibits the STAT3 signaling pathway. ALOX5 stabilizer-1 induces apoptosis in lung cancer cells and hampers their migration and proliferation, making it useful for research on non-small cell lung cancer (NSCLC).

ALOX5 stabilizer-1

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Catalog No. T213115

ALOX5 stabilizer-1

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

In vitro

ALOX5 stabilizer-1 (Compound 10d) effectively inhibits the proliferation of NCI-H820 cells with an IC 50 of 0.11 μM over 72 hours, while exhibiting lower toxicity on 3T3 cells with an IC 50 of 0.48 μM. In a dose-dependent manner, ALOX5 stabilizer-1 (0-0.2 μM, 10 days) suppresses colony formation of NCI-H820 cells. Additionally, at concentrations of 0-0.2 μM over 48 hours, it inhibits NCI-H820 cell migration and induces apoptosis. The compound directly targets the ALOX5 protein, enhancing its stability and consequently decreasing β-catenin protein levels, ultimately inhibiting the STAT3 signaling pathway in NCI-H820 cells.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc