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Anti-Thrombopoietin Antibody (7W14) is a Mouse antibody targeting Thrombopoietin. Anti-Thrombopoietin Antibody (7W14) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $92 | 7-10 days | |
100 μL | $292 | 7-10 days |
Description | Anti-Thrombopoietin Antibody (7W14) is a Mouse antibody targeting Thrombopoietin. Anti-Thrombopoietin Antibody (7W14) can be used in ELISA. |
Alias | TPO, thrombopoietin, THCYT1, MPLLG, ML, MKCSF, MGDF |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 7W14 |
Reactivity | Human |
Application | ELISA |
Recommended Dose | ELISA: 1:1000-1:2000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human THPO (rhTHPO; NP_000451.1Ser22-Gly353). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
Research Background | Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action. |
Conjucates | Unconjugated |
Immunogen | Human cell-derived rhTHPO |
Antigen Species | Human |
Biology Area | Serine Proteases and Regulators |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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