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Tanimilast

Catalog No. T38625 CAS 1239278-59-1

Synonyms: CHF-6001

Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammatory activity and is indicated for topical use in the lungs.Tanimilast was used in the study of obstructive lung disease.

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Tanimilast, CAS 1239278-59-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 280.00
5 mg	In stock	$ 689.00
10 mg	In stock	$ 983.00
25 mg	In stock	$ 1,460.00
50 mg	In stock	$ 1,970.00
100 mg	In stock	$ 2,650.00

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Purity: 98.34%

ee: 100%

Biological Description

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Description	Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammatory activity and is indicated for topical use in the lungs.Tanimilast was used in the study of obstructive lung disease.
Targets&IC50	PDE4:0.026±0.006 nM
In vitro	Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM; Guinea pig precision-cut lung slices). CHF-6001 did not affect airway closure and had limited effects on TGF-β1-induced remodeling, but rather, it inhibited methacholine-induced TGF-β release.[2]

Synonyms	CHF-6001
Molecular Weight	687.54
Formula	C30H30Cl2F2N2O8S
CAS No.	1239278-59-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Moretto N, et al. CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. 2. Kistemaker LEM, et al. The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices. Am J Physiol Lung Cell Mol Physiol. 2017;313(3):L507-L515. 3. Sulaiman I, et al. Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation. Pulm Pharmacol Ther. 2016;40:52-68. 4. Matera MG, et al. PDE inhibitors currently in early clinical trials for the treatment of asthma. Expert Opin Investig Drugs. 2014;23(9):1267-1275.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Keywords

Tanimilast 1239278-59-1 Metabolism PDE CHF 6001 CHF-6001 CHF6001 inhibitor inhibit

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