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Tanimilast

Name: Tanimilast
Brand: TargetMol
SKU: T38625
Price: 233 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T38625Cas No. 1239278-59-1

Alias CHF-6001

Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease.

Tanimilast

🥰Excellent

Purity: 98.34%

Catalog No. T38625Alias CHF-6001Cas No. 1239278-59-1

Pack Size	Price	Availability
1 mg	$233	In Stock
5 mg	$579	In Stock
10 mg	$868	In Stock
25 mg	$1,460	In Stock
50 mg	$1,970	In Stock
100 mg	$2,650	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.34%

ee:100%

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COA FNMR HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease.
Targets&IC50	PDE4:0.026±0.006 nM
In vitro	Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM; Guinea pig precision-cut lung slices). CHF-6001 did not affect airway closure and had limited effects on TGF-β1-induced remodeling, but rather, it inhibited methacholine-induced TGF-β release.[2]
Synonyms	CHF-6001

Chemical Properties

Molecular Weight	687.54
Formula	C₃₀H₃₀Cl₂F₂N₂O₈S
Cas No.	1239278-59-1
Smiles	[C@@H](CC=1C(Cl)=CN(=O)=CC1Cl)(OC(=O)C2=CC(OCC3CC3)=C(NS(C)(=O)=O)C=C2)C4=CC(OCC5CC5)=C(OC(F)F)C=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (72.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4545 mL	7.2723 mL	14.5446 mL	72.7230 mL
5 mM	0.2909 mL	1.4545 mL	2.9089 mL	14.5446 mL
10 mM	0.1454 mL	0.7272 mL	1.4545 mL	7.2723 mL
20 mM	0.0727 mL	0.3636 mL	0.7272 mL	3.6362 mL
50 mM	0.0291 mL	0.1454 mL	0.2909 mL	1.4545 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc