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GSK329

Name: GSK329
Brand: TargetMol
SKU: T24109
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24109Cas No. 1268490-12-5

Alias GSK-329, GSK 329

GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury.

GSK329

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Purity: 98%

Catalog No. T24109Alias GSK-329, GSK 329Cas No. 1268490-12-5

GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
2 mg	$69	-	In Stock
5 mg	$118	-	In Stock
10 mg	$193	-	In Stock
25 mg	$328	-	In Stock
50 mg	$472	-	In Stock
100 mg	$642	-	In Stock
200 mg	$865	-	In Stock
1 mL x 10 mM (in DMSO)	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

GSK329 AI Summary

GSK329 exhibits potent inhibitory activity against TNNI3K, as evidenced by its low IC50 values across various assays targeting this enzyme. It demonstrates selectivity towards TNNI3K over other kinases such as p38alpha and B-Raf, according to the selectivity index ratios. The compound also shows high binding affinity to full-length human His-MBP-TNNI3K and possesses high permeability. Furthermore, it has favorable pharmacokinetic properties in rats, including a reasonable half-life, dose-normalized AUC, and permeability profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury.
Synonyms	GSK-329, GSK 329

Chemical Properties

Molecular Weight	472.25
Formula	C₁₉H₁₄Cl₂F₃N₅O₂
Cas No.	1268490-12-5
Smiles	CNc1cc(Oc2c(Cl)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2Cl)ncn1
Relative Density.	1.554 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (529.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1175 mL	10.5876 mL	21.1752 mL	105.8761 mL
5 mM	0.4235 mL	2.1175 mL	4.2350 mL	21.1752 mL
10 mM	0.2118 mL	1.0588 mL	2.1175 mL	10.5876 mL
20 mM	0.1059 mL	0.5294 mL	1.0588 mL	5.2938 mL
50 mM	0.0424 mL	0.2118 mL	0.4235 mL	2.1175 mL
100 mM	0.0212 mL	0.1059 mL	0.2118 mL	1.0588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc