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ULK1-IN-2

Catalog No. T63343 CAS 2497409-01-3

ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ULK1-IN-2, CAS 2497409-01-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 690.00
100 mg	In stock	$ 1,120.00
500 mg	In stock	$ 2,230.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

ULK1-IN-2 (compound 3s) (10 μM; 24 h) exhibits potent anti-proliferative activity against A549, U937, HL60, MDA-MB-468, and MCF-7 cells. In A549 cells, ULK1-IN-2 hinders autophagy by inhibiting ULK1. Furthermore, ULK1-IN-2 induces apoptosis through the mitochondrial pathways in A549 cells in a dose-dependent manner and inhibits ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, leading to Bcl-2 expression significantly decrease and an increase in Bax and the active form of Caspase-3 expression.[1]

Molecular Weight	495.26
Formula	C19H16BrFN4O6
CAS No.	2497409-01-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (60.57 mM), Sonication is recommended.

References and Literature

1. Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max Autophagy Compound Library Bioactive Compound Library

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iCRT3 AZD-8055 Epothilone A Hesperetin Talampanel Diclofenac Potassium Sodium 4-phenylbutyrate Cladribine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ULK1-IN-2 2497409-01-3 Apoptosis Autophagy inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.