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Nevanimibe hydrochloride
🥰Excellent
Catalog No. T12225LCas No. 133825-81-7
Alias PD-132301 hydrochloride, ATR101 hydrochloride
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
Nevanimibe hydrochloride
🥰Excellent
Purity: 99.75%
Catalog No. T12225LAlias PD-132301 hydrochloride, ATR101 hydrochlorideCas No. 133825-81-7
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $87 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $463 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $787 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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Purity:99.75%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM. |
| Targets&IC50 | ACAT1:EC50 of 9 nM, ACAT2:368 nM (EC50) |
| In vitro | In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[2]. |
| Synonyms | PD-132301 hydrochloride, ATR101 hydrochloride |
| Molecular Weight | 458.08 |
| Formula | C27H40ClN3O |
| Cas No. | 133825-81-7 |
| Smiles | Cl.CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1ccc(cc1)N(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.67 mg/mL (90.97 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
PD-132301 HydrochloridePD132301 HydrochloridePD-132301PD132301PD 132301 HydrochloridePD 132301orallyO-acyltransferaseNevanimibe HydrochlorideNevanimibe hydrochlorideNevanimibemono- acylglycerol acyltransferaseInhibitorinhibitDiglyceride acyltransferaseDiacylglycerol acyltransferasecancerATR-101 HydrochlorideATR101 HydrochlorideATR-101ATR101ATR 101 HydrochlorideATR 101ApoptosisadrenocorticalAcyltransferaseacyl-coenzymeacyl-CoA:cholesterol acyltransferaseactiveACAT-1A:cholesterol
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