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Fluorometholone

Name: Fluorometholone
Brand: TargetMol
SKU: T3316
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3316Cas No. 426-13-1

Alias Oxylone, Fluoromethalone, Delmeson, Cortilet

Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

Fluorometholone

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Purity: 99.15%

Catalog No. T3316Alias Oxylone, Fluoromethalone, Delmeson, CortiletCas No. 426-13-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	In Stock	In Stock
50 mg	$60	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.15%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Fluorometholone AI Summary

Fluorometholone demonstrates a complex and varied pharmacological profile with significant bioactivities across several biological targets. It is potent in inhibiting aggregate formation in a cell model of Huntington disease (6309.6 nM), modulating miRNAs and activating miR-21 (4.1 nM), acting as an agonist and antagonist of the Hypoxia Response Element Signaling Pathway (10.0 nM each), inhibiting ROR gamma transcriptional activity (1771.1 nM and 446.7 nM), and inhibiting human alpha-Glucosidase as a potential chaperone treatment for Pompe Disease (177.8 nM). Additionally, it inhibits Chronic Active B-Cell Receptor Signaling (446.7 nM), Histone Lysine Methyltransferase G9a (89125.1 nM), Polymerase Kappa (89125.1 nM), and Marburg Virus binding or entry into cells (6513.1 nM). Fluorometholone also demonstrates variable growth inhibition against multiple human tumor cell lines, with GI50 values between 51204.37 nM and 100000.0 nM, and inhibits sodium fluorescein uptake in specific transfected CHO cells by significant percentages. Fluorometholone has a moderate lipophilic nature (LogD7.4 = 2.65), which can influence its bioavailability and cellular permeability. It also functions as a potent glucocorticoid receptor agonist with high affinity and shows affinity for progesterone and androgen receptors, albeit weaker. Importantly, no hepatic side effects are indicated based on DILIps assays. The compound exhibits bioactivity in activating human and rat Pregnane X Receptor (PXR) pathways and inhibition of human BSEP. Furthermore, Fluorometholone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 at a low MOI and presents conflicting antiviral activity against SARS-CoV-2 in different assay setups. It interacts with several receptors, demonstrating weak binding affinity and activities at concentrations above 10,000.0 nM, reflecting generally low potency towards these targets. Overall, Fluorometholone represents a multifaceted compound with therapeutic potential and diverse bioactive properties across multiple biological pathways and systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
Synonyms	Oxylone, Fluoromethalone, Delmeson, Cortilet

Chemical Properties

Molecular Weight	376.46
Formula	C₂₂H₂₉FO₄
Cas No.	426-13-1
Smiles	[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (146.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6563 mL	13.2816 mL	26.5632 mL	132.8162 mL
5 mM	0.5313 mL	2.6563 mL	5.3126 mL	26.5632 mL
10 mM	0.2656 mL	1.3282 mL	2.6563 mL	13.2816 mL
20 mM	0.1328 mL	0.6641 mL	1.3282 mL	6.6408 mL
50 mM	0.0531 mL	0.2656 mL	0.5313 mL	2.6563 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	1.3282 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc